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Literature summary extracted from

  • Dewamitta, S.R.; Nomura, T.; Kawamura, I.; Hara, H.; Tsuchiya, K.; Kurenuma, T.; Shen, Y.; Daim, S.; Yamamoto, T.; Qu, H.; Sakai, S.; Xu, Y.; Mitsuyama, M.
    Listeriolysin O-dependent bacterial entry into the cytoplasm is required for calpain activation and interleukin-1 alpha secretion in macrophages infected with Listeria monocytogenes (2010), Infect. Immun., 78, 1884-1894.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.52 (2S,3S)-trans-epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester broad-spectrum calpain inhibitor Mus musculus
3.4.22.52 calpastatin broad-spectrum calpain inhibitor Mus musculus
3.4.22.52 N-acetyl-L-leucyl-L-leucyl-L-norleucinal broad-spectrum calpain inhibitor Mus musculus
3.4.22.52 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-tyrosyl fluoromethylketone broad-spectrum calpain inhibitor Mus musculus
3.4.22.52 PD150606 specific inhibitor of calpain I Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.22.52 Ca2+ dependent on Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.52 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.52 macrophage
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.52 alpha-fodrin + H2O
-
 Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.52 calpain I
-
 Mus musculus

Expression

EC Number Organism Comment Expression
3.4.22.52 Mus musculus listeriolysin O-dependent bacterial entry into the cytoplasm is required for calpain activation and interleukin-1 alpha secretion in macrophages infected with Listeria monocytogenes up