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Literature summary extracted from

  • Peng, M.; Guo, S.; Yin, N.; Xue, J.; Shen, L.; Zhao, Q.; Zhang, W.
    Ectodomain shedding of Fcalpha receptor is mediated by ADAM10 and ADAM17 (2010), Immunology, 130, 83-91.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.86 EDTA 1 mM, treatment of cells dramatically inhibits shedding of shedding of FcalphaR, i.e. Fc receptor for immunoglobulin A Homo sapiens
3.4.24.86 EGTA 1 mM, treatment of cells dramatically inhibits shedding of shedding of FcalphaR, i.e. Fc receptor for immunoglobulin A Homo sapiens
3.4.24.86 GM6001 broad-spectrum metalloproteinase inhibitor, treatment of cells dramatically inhibits shedding of shedding of FcalphaR, i.e. Fc receptor for immunoglobulin A Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.81 FcalphaR + H2O Homo sapiens FcaR (CD89) is the Fc receptor for immunoglobulin A. ADAM10 and ADAM17 are involved in the shedding of FcalphaR ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.81 Homo sapiens
-
-
-
3.4.24.86 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.81 HEK-293T cell
-
 Homo sapiens
-
3.4.24.86 U-937 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.81 FcalphaR + H2O FcaR (CD89) is the Fc receptor for immunoglobulin A. ADAM10 and ADAM17 are involved in the shedding of FcalphaR Homo sapiens ?
-
 ?
3.4.24.81 FcalphaR + H2O FcaR (CD89) is the Fc receptor for immunoglobulin A Homo sapiens ?
-
 ?
3.4.24.86 FcalphaR + H2O i.e. Fc receptor for immunoglobulin A Homo sapiens ?
-
 ?

General Information

EC Number General Information Comment Organism
3.4.24.81 malfunction knockdown of both endogenous ADAM10 and endogenous ADAM17 inhibits FcalphaR shedding, demonstrating that ADAM10 and ADAM17 are involved in the shedding of FcalphaR Homo sapiens
3.4.24.86 physiological function knockdown of both endogenous ADAM10 and endogenous ADAM17 by siRNA inhibits FcalphaR, i.e. Fc receptor for immunoglobulin A, shedding Homo sapiens