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Literature summary extracted from

  • Stewart, J.M.; Ocon, A.J.; Clarke, D.; Taneja, I.; Medow, M.S.
    Defects in cutaneous angiotensin-converting enzyme 2 and angiotensin-(1-7) production in postural tachycardia syndrome (2009), Hypertension, 53, 767-774.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.23 Ac-GDYSHCSPLRYYPWWPDPEGGG-NH2 i.e. DX600 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.17.23 angiotensin II + H2O Homo sapiens
-
 angiotensin(1-7) + L-Phe
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.23 skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.23 angiotensin II + H2O
-
 Homo sapiens angiotensin(1-7) + L-Phe
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.23 ACE2
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.17.23 malfunction postural tachycardia syndrome is associated with increased plasma angiotensin-II. ACE2 effects are blunted in low flow postural tachycardia syndrome, POTS, and restored by the ACE2 product angiotensin-(1-7) Homo sapiens
3.4.17.23 physiological function ACE2 is involved in the angiotensin-II-mediated vasodilation Homo sapiens