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Literature summary extracted from

  • Masson, R.; Nicklin, S.A.; Craig, M.A.; McBride, M.; Gilday, K.; Gregorevic, P.; Allen, J.M.; Chamberlain, J.S.; Smith, G.; Graham, D.; Dominiczak, A.F.; Napoli, C.; Baker, A.H.
    Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2 (2009), Hypertension, 53, 694-700.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.17.23 overexpression of ACE2, by usage of a recombinant adeno-associated virus 6 delivery system, in myocardium of stroke-prone spontaneously hypertensive rats, gene expression profiling, overview Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.17.23 additional information ACE2 overexpression leads to markedly increased myocyte volume, assessed in primary rabbit myocytes Oryctolagus cuniculus
3.4.17.23 additional information overexpression of ACE2, by usage of a recombinant adeno-associated virus 6 delivery system, in myocardium of stroke-prone spontaneously hypertensive rats mediates onset of experimental severe cardiac fibrosis Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.17.23 angiotensin II + H2O Rattus norvegicus
-
 angiotensin(1-7) + L-Phe
-
 ?
3.4.17.23 angiotensin II + H2O Oryctolagus cuniculus
-
 angiotensin(1-7) + L-Phe
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Oryctolagus cuniculus
-
-
-
3.4.17.23 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.23 cell culture
-
 Oryctolagus cuniculus
-
3.4.17.23 heart
-
 Rattus norvegicus
-
3.4.17.23 heart
-
 Oryctolagus cuniculus
-
3.4.17.23 myocardium
-
 Rattus norvegicus
-
3.4.17.23 myocyte
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.23 angiotensin II + H2O
-
 Rattus norvegicus angiotensin(1-7) + L-Phe
-
 ?
3.4.17.23 angiotensin II + H2O
-
 Oryctolagus cuniculus angiotensin(1-7) + L-Phe
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.23 ACE2
-
 Oryctolagus cuniculus

General Information

EC Number General Information Comment Organism
3.4.17.23 physiological function role of ACE2 in the regulation of cardiac structure and function, as well as maintenance of systemic blood pressure, overview Oryctolagus cuniculus