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Literature summary extracted from

  • Simonin, Y.; Disson, O.; Lerat, H.; Antoine, E.; Biname, F.; Rosenberg, A.R.; Desagher, S.; Lassus, P.; Bioulac-Sage, P.; Hibner, U.
    Calpain activation by hepatitis C virus proteins inhibits the extrinsic apoptotic signaling pathway (2009), Hepatology, 50, 1370-1379.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.22.52 NS5A protein the nonstructural hepatitis C virus protein NS5Ais sufficient to activate a calpain 1 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.52 E64d
-
 Homo sapiens
3.4.22.52 MDL-28170
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.52 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.52 Huh-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.52 BH3-only Bcl2 interacting domain + H2O BH3-only Bcl2 interacting domain is a direct target of a soluble active calpain 1 present in cells expressing hepatitis C virus proteins Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.52 calpain 1
-
 Homo sapiens