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Literature summary extracted from

  • Olsen, I.; Balasingham, S.V.; Davidsen, T.; Debebe, E.; Rodland, E.A.; van Soolingen, D.; Kremer, K.; Alseth, I.; Tonjum, T.
    Characterization of the major formamidopyrimidine-DNA glycosylase homolog in Mycobacterium tuberculosis and its linkage to variable tandem repeats (2009), FEMS Immunol. Med. Microbiol., 56, 151-161.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.2.23 gene Rv2924c encoding Mtb-Fpg1, DNA and amino acid sequence determination and analysis, relationship between tandem repeat length and Mtb-fpg1 expression levels, quantitative expression analysis, overview Mycobacterium tuberculosis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.2.2.23 31950
-
 x * 31950, Mtb-Fpg1, sequence calculation, x * 32000, recombinant Mtb-Fpg1, SDS-PAGE Mycobacterium tuberculosis
3.2.2.23 32000
-
 x * 31950, Mtb-Fpg1, sequence calculation, x * 32000, recombinant Mtb-Fpg1, SDS-PAGE Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.23 Mycobacterium tuberculosis P9WNC3
-
-
3.2.2.23 Mycobacterium tuberculosis P9WNC3 gene Rv2924c
-
3.2.2.23 Mycobacterium tuberculosis H37Rv P9WNC3
-
-
3.2.2.23 Mycobacterium tuberculosis H37Rv P9WNC3 gene Rv2924c
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.2.2.23 recombinant Mtb-Fpg1 to homogeneity Mycobacterium tuberculosis

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.2.23 additional information molecular strain typing, and enzyme expression level, overview Mycobacterium tuberculosis
-
3.2.2.23 additional information molecular strain typing, and enzyme expression levels in strain H37Rv and other isolates, overview Mycobacterium tuberculosis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.23 additional information Mtb-Fpg1 removes formamidopyrimidine and 5-hydroxycytosine lesions, as well as 8-oxo-7,8-dihydroguanine opposite to C, T and G. Substrates are duplex DNA substrates containing a single 8oxoG opposite of C, A, G, T, 5-hydroxycytosine (5OHC):G, 5-hydroxyuracil (5OHU):G, DHU:G, U:A or U:G base pair Mycobacterium tuberculosis ?
-
 ?
3.2.2.23 additional information Mtb-Fpg1 removes formamidopyrimidine and 5-hydroxycytosine lesions, as well as 8-oxo-7,8-dihydroguanine opposite to C, T and G. Substrates are duplex DNA substrates containing a single 8oxoG opposite of C, A, G, T, 5-hydroxycytosine (5OHC):G, 5-hydroxyuracil (5OHU):G, DHU:G, U:A or U:G base pair Mycobacterium tuberculosis H37Rv ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.2.2.23 ? x * 31950, Mtb-Fpg1, sequence calculation, x * 32000, recombinant Mtb-Fpg1, SDS-PAGE Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
3.2.2.23 Fapy-DNA glycosylase
-
 Mycobacterium tuberculosis
3.2.2.23 formamidopyrimidine-DNA glycosylase
-
 Mycobacterium tuberculosis
3.2.2.23 FPG
-
 Mycobacterium tuberculosis
3.2.2.23 Mtb-Fpg1
-
 Mycobacterium tuberculosis