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Literature summary extracted from

  • Issuree, P.D.; Pushparaj, P.N.; Pervaiz, S.; Melendez, A.J.
    Resveratrol attenuates C5a-induced inflammatory responses in vitro and in vivo by inhibiting phospholipase D and sphingosine kinase activities (2009), FASEB J., 23, 2412-2424.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.4 1-butanol treatment of human neutrophils to butan-1-ol significantly dampenes functional responses such as degranualtion, chemotaxis, and oxidative burst Homo sapiens
3.1.4.4 1-butanol
-
 Mus musculus
3.1.4.4 resveratrol a phytoalexin with antiinflammatory activity in C5 anaphylatoxin-stimulated primary neutrophils, blocks PLD activity and membrane recruitment Homo sapiens
3.1.4.4 resveratrol a phytoalexin with antiinflammatory activity in C5 anaphylatoxin-stimulated primary neutrophils and in a mouse model of acute peritonitis, blocks PLD activity and membrane recruitment Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.4 plasma membrane translocation of OLD to the plasma membrane Mus musculus 5886
-
3.1.4.4 plasma membrane translocation of OLD to the plasma membrane Homo sapiens 5886
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Homo sapiens
-
-
-
3.1.4.4 Mus musculus
-
 male BALB/c mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 HL-60 cell
-
 Homo sapiens
-
3.1.4.4 neutrophil C5 anaphylatoxin-stimulated primary neutrophils Mus musculus
-
3.1.4.4 neutrophil C5 anaphylatoxin-stimulated primary neutrophils Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.1.4.4 PLD
-
 Mus musculus
3.1.4.4 PLD
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.4 37
-
 assay at Mus musculus
3.1.4.4 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.4 7.4
-
 assay at Mus musculus
3.1.4.4 7.4
-
 assay at Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.4.4 malfunction pretreatment of human neutrophils with PLD inhibitor resveratrol significantly blocks oxidative burst, leukocyte migration, degranulation, and inflammatory cytokine production involving inhibition of sphingosine kinase activity and ERK1/2 phosphorylation Homo sapiens
3.1.4.4 malfunction pretreatment of mouse neutrophils with PLD inhibitor resveratrol significantly blocks oxidative burst, leukocyte migration, degranulation, and inflammatory cytokine production involving inhibition of sphingosine kinase activity and ERK1/2 phosphorylation Mus musculus