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Literature summary extracted from

  • Li, Q.; Fang, H.; Wang, X.; Xu, W.
    Novel cyclic-imide peptidomimetics as aminopeptidase N inhibitors. Structure-based design, chemistry and activity evaluation. II (2010), Eur. J. Med. Chem., 45, 1618-1626.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.2 (S)-2-amino-N-((S)-1-(2-(hydroxyamino)-2-oxoethyl)-2,6-dioxopiperidin-3-yl)-2-((R)-pyrrolidin-2-yl)acetamide
-
 Sus scrofa
3.4.11.2 bestatin
-
 Sus scrofa
3.4.11.2 ethyl (S)-2-(3-(2-aminoacetamido)-2,6-dioxopiperidin-1-yl)acetate
-
 Sus scrofa
3.4.11.2 ethyl [(3S)-2,6-dioxo-3-(phenylalanylamino)piperidin-1-yl]acetate
-
 Sus scrofa
3.4.11.2 ethyl [(3S)-2,6-dioxo-3-(tryptophylamino)piperidin-1-yl]acetate
-
 Sus scrofa
3.4.11.2 ethyl [(3S)-2,6-dioxo-3-(tyrosylamino)piperidin-1-yl]acetate
-
 Sus scrofa
3.4.11.2 ethyl [(3S)-2,6-dioxo-3-(valylamino)piperidin-1-yl]acetate
-
 Sus scrofa
3.4.11.2 ethyl [(3S)-3-(alanylamino)-2,6-dioxopiperidin-1-yl]acetate
-
 Sus scrofa
3.4.11.2 ethyl [(3S)-3-(histidylamino)-2,6-dioxopiperidin-1-yl]acetate
-
 Sus scrofa
3.4.11.2 ethyl [(3S)-3-(isoleucylamino)-2,6-dioxopiperidin-1-yl]acetate
-
 Sus scrofa
3.4.11.2 ethyl [(3S)-3-(leucylamino)-2,6-dioxopiperidin-1-yl]acetate
-
 Sus scrofa
3.4.11.2 ethyl [(3S)-3-(lysylamino)-2,6-dioxopiperidin-1-yl]acetate
-
 Sus scrofa
3.4.11.2 ethyl [(3S)-3-(methionylamino)-2,6-dioxopiperidin-1-yl]acetate
-
 Sus scrofa
3.4.11.2 ethyl [(3S)-3-{[(2S)-2-amino-2-(pyrrolidin-2-yl)acetyl]amino}-2,6-dioxopiperidin-1-yl]acetate
-
 Sus scrofa
3.4.11.2 N-[(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl]-3,4,5-trimethoxybenzamide
-
 Sus scrofa
3.4.11.2 N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}alaninamide
-
 Sus scrofa
3.4.11.2 N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}glycinamide
-
 Sus scrofa
3.4.11.2 N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}isoleucinamide
-
 Sus scrofa
3.4.11.2 N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}leucinamide
-
 Sus scrofa
3.4.11.2 N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}lysinamide
-
 Sus scrofa
3.4.11.2 N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}phenylalaninamide
-
 Sus scrofa
3.4.11.2 N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}tyrosinamide
-
 Sus scrofa
3.4.11.2 N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}valinamide
-
 Sus scrofa
3.4.11.2 [(3S)-2,6-dioxo-3-(phenylalanylamino)piperidin-1-yl]acetic acid
-
 Sus scrofa
3.4.11.2 [(3S)-2,6-dioxo-3-(tyrosylamino)piperidin-1-yl]acetic acid
-
 Sus scrofa
3.4.11.2 [(3S)-2,6-dioxo-3-(valylamino)piperidin-1-yl]acetic acid
-
 Sus scrofa
3.4.11.2 [(3S)-3-(alanylamino)-2,6-dioxopiperidin-1-yl]acetic acid
-
 Sus scrofa
3.4.11.2 [(3S)-3-(glycylamino)-2,6-dioxopiperidin-1-yl]acetic acid
-
 Sus scrofa
3.4.11.2 [(3S)-3-(isoleucylamino)-2,6-dioxopiperidin-1-yl]acetic acid
-
 Sus scrofa
3.4.11.2 [(3S)-3-(leucylamino)-2,6-dioxopiperidin-1-yl]acetic acid
-
 Sus scrofa
3.4.11.2 [(3S)-3-(lysylamino)-2,6-dioxopiperidin-1-yl]acetic acid
-
 Sus scrofa
3.4.11.2 [(3S)-3-{[(2S)-2-amino-2-(pyrrolidin-2-yl)acetyl]amino}-2,6-dioxopiperidin-1-yl]acetic acid
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.2 microsome
-
 Sus scrofa
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.2 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.2 kidney
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.2 L-Leu-4-nitroanilide + H2O
-
 Sus scrofa L-Leu + 4-nitroaniline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.2 aminopeptidase N
-
 Sus scrofa
3.4.11.2 APN
-
 Sus scrofa
3.4.11.2 CD13
-
 Sus scrofa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.11.2 0.0018
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}phenylalaninamide
3.4.11.2 0.0024
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa bestatin
3.4.11.2 0.0031
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa N-[(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl]-3,4,5-trimethoxybenzamide
3.4.11.2 0.0053
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}leucinamide
3.4.11.2 0.0073
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}tyrosinamide
3.4.11.2 0.0092
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}isoleucinamide
3.4.11.2 0.0094
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}glycinamide
3.4.11.2 0.0094
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}lysinamide
3.4.11.2 0.0097
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (S)-2-amino-N-((S)-1-(2-(hydroxyamino)-2-oxoethyl)-2,6-dioxopiperidin-3-yl)-2-((R)-pyrrolidin-2-yl)acetamide
3.4.11.2 0.0109
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}alaninamide
3.4.11.2 0.0113
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa [(3S)-2,6-dioxo-3-(tyrosylamino)piperidin-1-yl]acetic acid
3.4.11.2 0.0125
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa N-{(3S)-1-[2-(hydroxyamino)-2-oxoethyl]-2,6-dioxopiperidin-3-yl}valinamide
3.4.11.2 0.0132
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa [(3S)-3-{[(2S)-2-amino-2-(pyrrolidin-2-yl)acetyl]amino}-2,6-dioxopiperidin-1-yl]acetic acid
3.4.11.2 0.0141
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa [(3S)-3-(lysylamino)-2,6-dioxopiperidin-1-yl]acetic acid
3.4.11.2 0.0154
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa [(3S)-3-(glycylamino)-2,6-dioxopiperidin-1-yl]acetic acid
3.4.11.2 0.0158
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa [(3S)-2,6-dioxo-3-(valylamino)piperidin-1-yl]acetic acid
3.4.11.2 0.0166
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa [(3S)-3-(isoleucylamino)-2,6-dioxopiperidin-1-yl]acetic acid
3.4.11.2 0.0169
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa ethyl [(3S)-2,6-dioxo-3-(tyrosylamino)piperidin-1-yl]acetate
3.4.11.2 0.0169
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa [(3S)-2,6-dioxo-3-(phenylalanylamino)piperidin-1-yl]acetic acid
3.4.11.2 0.0189
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa ethyl [(3S)-3-(histidylamino)-2,6-dioxopiperidin-1-yl]acetate
3.4.11.2 0.0207
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa ethyl [(3S)-2,6-dioxo-3-(tryptophylamino)piperidin-1-yl]acetate
3.4.11.2 0.0215
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa [(3S)-3-(alanylamino)-2,6-dioxopiperidin-1-yl]acetic acid
3.4.11.2 0.0221
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa [(3S)-3-(leucylamino)-2,6-dioxopiperidin-1-yl]acetic acid
3.4.11.2 0.0233
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa ethyl [(3S)-3-(isoleucylamino)-2,6-dioxopiperidin-1-yl]acetate
3.4.11.2 0.0237
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa ethyl (S)-2-(3-(2-aminoacetamido)-2,6-dioxopiperidin-1-yl)acetate
3.4.11.2 0.0288
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa ethyl [(3S)-2,6-dioxo-3-(valylamino)piperidin-1-yl]acetate
3.4.11.2 0.0308
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa ethyl [(3S)-3-(leucylamino)-2,6-dioxopiperidin-1-yl]acetate
3.4.11.2 0.0321
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa ethyl [(3S)-3-{[(2S)-2-amino-2-(pyrrolidin-2-yl)acetyl]amino}-2,6-dioxopiperidin-1-yl]acetate
3.4.11.2 0.0381
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa ethyl [(3S)-2,6-dioxo-3-(phenylalanylamino)piperidin-1-yl]acetate
3.4.11.2 0.041
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa ethyl [(3S)-3-(lysylamino)-2,6-dioxopiperidin-1-yl]acetate
3.4.11.2 0.042
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa ethyl [(3S)-3-(methionylamino)-2,6-dioxopiperidin-1-yl]acetate
3.4.11.2 0.0643
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa ethyl [(3S)-3-(alanylamino)-2,6-dioxopiperidin-1-yl]acetate