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Literature summary extracted from

  • Zeng, X.X.; Zheng, X.; Xiang, Y.; Cho, H.P.; Jessen, J.R.; Zhong, T.P.; Solnica-Krezel, L.; Brown, H.A.
    Phospholipase D1 is required for angiogenesis of intersegmental blood vessels in zebrafish (2009), Dev. Biol., 328, 363-376.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.4 gene pld1, in vitro transcription and translation Danio rerio

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.4 additional information generation of mosaic pld1 deficient embryos, that show partial suppression of intersegmental vessel defects in the segments containing transplanted wild-type somitic and notochord cells, or notochord cells alone. 1-Butanol treatment phenocopies the ISV defects of pld1 morphants, overview. The early chordamesoderm marker shh is normally downregulated in pld1 morphants or 1-butanol treated embryos, ths notochord differentiation is not affected when Pld1 function is disrupted. No changes in VEGF and semaphorins 3a1 expressions Danio rerio

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.4 1-butanol
-
 Danio rerio

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.4 phosphatidylcholine + H2O Danio rerio
-
 choline + phosphatidic acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Danio rerio
-
 gene pld1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 embryo
-
 Danio rerio
-
3.1.4.4 additional information dynamic expression pattern of pld1 during early zebrafish development, overview Danio rerio
-
3.1.4.4 notochord
-
 Danio rerio
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.4 phosphatidylcholine + H2O
-
 Danio rerio choline + phosphatidic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.4 PLD
-
 Danio rerio
3.1.4.4 PLD1
-
 Danio rerio

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.4 37
-
 assay at Danio rerio

General Information

EC Number General Information Comment Organism
3.1.4.4 malfunction inhibition of Pld1 function, by siRNA-mediated downregulation or 1-butanol, does not strongly impair the dorsal-ventral guidance of primary/secondary motor axons Danio rerio
3.1.4.4 physiological function activity of Pld1 in the developing notochord is essential for vascular development in vertebrates. Pld1 may regulate the ISV development through a parallel pathway controlling angiogenesis or play a role downstream of these angiogenic pathways, overview Danio rerio