EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.73 | additional information | increase of uPA activity and expression by freezing/thawing process in porcine uterus endometrial epithelium cells | Sus scrofa |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.73 | additional information | the MAP kinase inhibitors SP600125, a JNK inhibitor, and SB203580, a p38 inhibitor, do not inhibit uPA in frozen-thawed porcine uterus endometrial epithelium cells | Sus scrofa | |
3.4.21.73 | PAI-1 | - |
Sus scrofa | |
3.4.21.73 | PD98059 | the ERK MAP kinase inhibitor dramatically reduces the uPA expression in the frozen-thawed porcine uterus endometrial epithelium cells | Sus scrofa |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.73 | plasminogen + H2O | Sus scrofa | - |
plasmin + ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.73 | Sus scrofa | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.21.73 | endometrium | primary | Sus scrofa | - |
3.4.21.73 | epithelial cell | primary | Sus scrofa | - |
3.4.21.73 | uterine endometrium | - |
Sus scrofa | - |
3.4.21.73 | uterus | - |
Sus scrofa | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.73 | plasminogen + H2O | - |
Sus scrofa | plasmin + ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.73 | uPA | - |
Sus scrofa |
3.4.21.73 | urokinase-type PA | - |
Sus scrofa |
EC Number | Organism | Comment | Expression |
---|---|---|---|
3.4.21.73 | Sus scrofa | in human endometrial cells, uPA and PAI-1 expression is regulated by steroid hormones such as estradiol, and progesterone. P4 suppresses uPA in epithelial cells and enhances inhibitor PAI-1 expression in both epithelial and stromal cells | down |
3.4.21.73 | Sus scrofa | increase of uPA activity and expression by freezing/thawing process in porcine uterus endometrial epithelium cells. Reactive oxygen species, that occur in high rates in response to the freezing-thawing stimulus, actively participate in the induction of uPA expression in frozen-thawed and in vitro-cultured cells | up |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.4.21.73 | additional information | plasminogen activators are serine proteases that are classified as either urokinase-type PA, uPA, or tissue-type PA, tPA, based on their molecular mass | Sus scrofa |