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Literature summary extracted from

  • Huang, M.L.; Li, X.; Meng, Y.; Xiao, B.; Ma, Q.; Ying, S.S.; Wu, P.S.; Zhang, Z.S.
    Upregulation of angiotensin-converting enzyme (ACE) 2 in hepatic fibrosis by ACE inhibitors (2010), Clin. Exp. Pharmacol. Physiol., 37, e1-e6.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.17.23 ACE2 expression analysis by RT-PCR Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.23 additional information ACE2 is insensitive to ACE inhibitors Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.17.23 angiotensin II + H2O Rattus norvegicus
-
 angiotensin(1-7) + L-Phe
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Rattus norvegicus
-
 male Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.23 connective tissue
-
 Rattus norvegicus
-
3.4.17.23 hepatic stellate cell
-
 Rattus norvegicus
-
3.4.17.23 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.23 angiotensin II + H2O
-
 Rattus norvegicus angiotensin(1-7) + L-Phe
-
 ?
3.4.17.23 angiotensin II + H2O i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Rattus norvegicus angiotensin(1-7) + L-Phe i.e. Asp-Arg-Val-Tyr-Ile-His-Pro ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.23 ACE2
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
3.4.17.23 Rattus norvegicus the enzyme expression is upregulated in case of induced liver fibrosis and is further upregulated by additional administration of ACE I inhibitor peptide, pGlu-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro, in hepatic stellate cells up

General Information

EC Number General Information Comment Organism
3.4.17.23 physiological function ACE 2 balances the status of the renin-angiotensin system by degrading angiotensin II and generating angiotensin-(1-7). ACE2 induces overexpression of connective tissue growth factor, which is inhibited by blockade of theMas receptor with A779, overview Rattus norvegicus