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Literature summary extracted from

  • de Carvalho, L.P.; Zhao, H.; Dickinson, C.E.; Arango, N.M.; Lima, C.D.; Fischer, S.M.; Ouerfelli, O.; Nathan, C.; Rhee, K.Y.
    Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase (2010), Chem. Biol., 17, 323-332.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.2.1.5 Mg2+ strictly dependent on Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.2.1.5 additional information Mycobacterium tuberculosis catalyzing C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of a second substrate, glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA) ?
-
 ?
2.2.1.5 additional information Mycobacterium tuberculosis Rv1248c catalyzes C-C bond formation between the activated aldehyde of alpha-ketoglutarate and the carbonyl of glyoxylate to yield 2-hydroxy-3-oxoadipate (HOA), which decomposes to 5-hydroxylevulinate ?
-
 ?
2.2.1.5 additional information Mycobacterium tuberculosis H37Rv catalyzing C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of a second substrate, glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA) ?
-
 ?
2.2.1.5 additional information Mycobacterium tuberculosis H37Rv Rv1248c catalyzes C-C bond formation between the activated aldehyde of alpha-ketoglutarate and the carbonyl of glyoxylate to yield 2-hydroxy-3-oxoadipate (HOA), which decomposes to 5-hydroxylevulinate ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.2.1.5 Mycobacterium tuberculosis P9WIS5 protein is originally annotated as the alpha-ketoglutarate (alpha-KG) decarboxylase (E1) component of alpha-KG dehydrogenase complex. The physiological activity of Rv1248c as that of a carboligase established by activity-based metabolomic profiling
-
2.2.1.5 Mycobacterium tuberculosis H37Rv P9WIS5 protein is originally annotated as the alpha-ketoglutarate (alpha-KG) decarboxylase (E1) component of alpha-KG dehydrogenase complex. The physiological activity of Rv1248c as that of a carboligase established by activity-based metabolomic profiling
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.2.1.5 2-oxoglutarate + glyoxylate
-
 Mycobacterium tuberculosis 2-hydroxy-3-oxoadipate + CO2
-
 ?
2.2.1.5 2-oxoglutarate + glyoxylate
-
 Mycobacterium tuberculosis H37Rv 2-hydroxy-3-oxoadipate + CO2
-
 ?
2.2.1.5 additional information catalyzing C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of a second substrate, glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA) Mycobacterium tuberculosis ?
-
 ?
2.2.1.5 additional information Rv1248c catalyzes C-C bond formation between the activated aldehyde of alpha-ketoglutarate and the carbonyl of glyoxylate to yield 2-hydroxy-3-oxoadipate (HOA), which decomposes to 5-hydroxylevulinate Mycobacterium tuberculosis ?
-
 ?
2.2.1.5 additional information enzyme catalyzes consumption of 2-oxoglutarate in a mycobacterial small molecule extract with matched production of 5-hydroxylevulinate (HLA) in a reaction predicted to require glyoxylate Mycobacterium tuberculosis ?
-
 ?
2.2.1.5 additional information catalyzing C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of a second substrate, glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA) Mycobacterium tuberculosis H37Rv ?
-
 ?
2.2.1.5 additional information Rv1248c catalyzes C-C bond formation between the activated aldehyde of alpha-ketoglutarate and the carbonyl of glyoxylate to yield 2-hydroxy-3-oxoadipate (HOA), which decomposes to 5-hydroxylevulinate Mycobacterium tuberculosis H37Rv ?
-
 ?
2.2.1.5 additional information enzyme catalyzes consumption of 2-oxoglutarate in a mycobacterial small molecule extract with matched production of 5-hydroxylevulinate (HLA) in a reaction predicted to require glyoxylate Mycobacterium tuberculosis H37Rv ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.2.1.5 2-hydroxy-3-oxoadipate synthase
-
 Mycobacterium tuberculosis
2.2.1.5 carboligase
-
 Mycobacterium tuberculosis
2.2.1.5 HOA synthase
-
 Mycobacterium tuberculosis
2.2.1.5 Rv1248c
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
2.2.1.5 thiamine diphosphate strictly dependent on Mycobacterium tuberculosis