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Literature summary extracted from

  • Matta, C.; Fodor, J.; Szijgyarto, Z.; Juhasz, T.; Gergely, P.; Csernoch, L.; Zakany, R.
    Cytosolic free Ca2+ concentration exhibits a characteristic temporal pattern during in vitro cartilage differentiation: a possible regulatory role of calcineurin in Ca-signalling of chondrogenic cells (2008), Cell Calcium, 44, 310-323.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.16 Calmodulin calcineurin is dependent on Ca2+/calmodulin Gallus gallus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.16 A23187 reduces the Ca2+ level and thereby inhibits Ca2+-dependent calcineurin Gallus gallus
3.1.3.16 cyclosporin A in vivo inhibition in cell culture, 40% inhibition at 0.002 mM in vitro Gallus gallus
3.1.3.16 EGTA reduces the Ca2+ level and thereby inhibits Ca2+-dependent calcineurin Gallus gallus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.16 Ca2+ calcineurin is dependent on Ca2+/calmodulin Gallus gallus

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.16 Gallus gallus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.16 cell culture
-
 Gallus gallus
-
3.1.3.16 chondrogenic cell from distal parts of the limb buds of 4-day-old Ross hybrid chicken embryos Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.16 phosphorylated protein phosphatase inhibitor-1 + H2O
-
 Gallus gallus protein phosphatase inhibitor-1 + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.16 Ca-calmodulin-dependent protein phosphatase
-
 Gallus gallus
3.1.3.16 calcineurin
-
 Gallus gallus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.3.16 30
-
 assay at Gallus gallus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.16 7
-
 assay at Gallus gallus

General Information

EC Number General Information Comment Organism
3.1.3.16 physiological function calcineurin is one of the target molecules regulated by the changes of intracellular Ca2+ level, it has a regulatory role in Ca2+ cytosolic concentration and signaling in chondrogenic cells, Ca2+ plays an important role in chondrogenesis, cartilage formation and cartilage differentiation, overview Gallus gallus