BRENDA - Enzyme Database show

Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system

Yoshikawa, K.; Takei, S.; Hasegawa-Ishii, S.; Chiba, Y.; Furukawa, A.; Kawamura, N.; Hosokawa, M.; Woodward, D.F.; Watanabe, K.; Shimada, A.; Brain Res. 1367, 22-32 (2011)

Data extracted from this reference:

Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.1.1.188
cytoplasm
cultured oligodendrocytes at 7 days in vitro express the enzyme in cytoplasmic processes where the enzyme is co-localized with myelin basic protein
Mus musculus
5737
-
1.11.1.20
cytoplasm
cultured oligodendrocytes at 7 days in vitro express the enzyme in cytoplasmic processes where the enzyme is colocalized with myelin basic protein
Mus musculus
5737
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.11.1.20
thioredoxin + (5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide
Mus musculus
(5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide i.e. prostamide H2. The product of the reaction prostamide F2alpha is a COX-2-catalyzed metabolite of arachidonoyl ethanolamide that induces important pharmacological actions via interaction with a putative prostamide receptor
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide
(5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide i.e. prostamide F2alpha
-
?
1.11.1.20
thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate
Mus musculus
(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate i.e. prostaglandin H2. The product of the reaction prostaglandin F2alpha induces luteolysis in the estrous cycle and plays essential roles in parturition with its strong uterine contractile actions and has vasoconstriction and bronchoconstriction activities. PGF2alpha exerts these biological functions by binding to the FP receptor, a G-protein-coupled receptor that signals through Gq-mediated increases in intracellular calcium
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate
(5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate i.e. prostaglandin F2alpha
-
?
1.11.1.20
thioredoxin + prostaglandin H2
Mus musculus
-
thioredoxin disulfide + prostaglandin F2alpha
-
-
?
1.11.1.20
thioredoxin + prostamide H2
Mus musculus
-
thioredoxin disulfide + prostamide F2alpha
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.188
Mus musculus
-
-
-
1.11.1.20
Mus musculus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.188
brain
enzyme is expressed preferentially in the white matter bundles of the entire central nervous system of adult mice with less marked expression inneuronal cell bodies. The enzyme co-localizes with myelin basic protein in myelin sheaths but not in axons
Mus musculus
-
1.1.1.188
myelin
enzyme co-localizes with myelin basic protein in myelin sheaths but not in axons
Mus musculus
-
1.1.1.188
oligodendrocyte
cultured oligodendrocytes at 7 days in vitro express the enzyme in cytoplasmic processes where the enzyme is co-localized with myelin basic protein
Mus musculus
-
1.11.1.20
brain
the enzyme is expressed preferentially in the white matter bundles of the entire central nervous system of adult mice with less marked expression in neuronal cell bodies. The enzyme is colocalized with myelin basic protein in myelin sheaths but not in axons. At the ultrastructural level, the enzyme is localized to myelin sheaths. Expression of the enzyme increases between postnatal day 9 and postnatal day 14 during the postnatal development, presumably in accordance with myelinogenesis
Mus musculus
-
1.11.1.20
central nervous system
prostamide/PGF synthase is expressed preferentially in the white matter bundles of the entire central nervous system of adult mice with less marked expression in neuronal cell bodies
Mus musculus
-
1.11.1.20
cerebellar cortex
-
Mus musculus
-
1.11.1.20
medulla oblongata
-
Mus musculus
-
1.11.1.20
myelin sheath
the enzyme is colocalized with myelin basic protein in myelin sheaths but not in axons
Mus musculus
-
1.11.1.20
oligodendrocyte
; cultured oligodendrocytes at 7 days in vitro express the enzyme in cytoplasmic processes where the enzyme is colocalized with myelin basic protein
Mus musculus
-
1.11.1.20
pons
-
Mus musculus
-
1.11.1.20
spinal cord
-
Mus musculus
-
1.11.1.20
white matter
there is a tendency for the white matter bundles in the spinal cord, medulla oblongata, pons, and cerebellar medulla to express prostamide/PGF synthase more strongly than those in other central nervous system regions
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.11.1.20
thioredoxin + (5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide
(5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide i.e. prostamide H2. The product of the reaction prostamide F2alpha is a COX-2-catalyzed metabolite of arachidonoyl ethanolamide that induces important pharmacological actions via interaction with a putative prostamide receptor
707934
Mus musculus
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide
(5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide i.e. prostamide F2alpha
-
-
?
1.11.1.20
thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate
(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate i.e. prostaglandin H2. The product of the reaction prostaglandin F2alpha induces luteolysis in the estrous cycle and plays essential roles in parturition with its strong uterine contractile actions and has vasoconstriction and bronchoconstriction activities. PGF2alpha exerts these biological functions by binding to the FP receptor, a G-protein-coupled receptor that signals through Gq-mediated increases in intracellular calcium
707934
Mus musculus
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate
(5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate i.e. prostaglandin F2alpha
-
-
?
1.11.1.20
thioredoxin + prostaglandin H2
-
707934
Mus musculus
thioredoxin disulfide + prostaglandin F2alpha
-
-
-
?
1.11.1.20
thioredoxin + prostamide H2
-
707934
Mus musculus
thioredoxin disulfide + prostamide F2alpha
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.11.1.20
thioredoxin
-
Mus musculus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.11.1.20
thioredoxin
-
Mus musculus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.1.1.188
cytoplasm
cultured oligodendrocytes at 7 days in vitro express the enzyme in cytoplasmic processes where the enzyme is co-localized with myelin basic protein
Mus musculus
5737
-
1.11.1.20
cytoplasm
cultured oligodendrocytes at 7 days in vitro express the enzyme in cytoplasmic processes where the enzyme is colocalized with myelin basic protein
Mus musculus
5737
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.11.1.20
thioredoxin + (5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide
Mus musculus
(5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide i.e. prostamide H2. The product of the reaction prostamide F2alpha is a COX-2-catalyzed metabolite of arachidonoyl ethanolamide that induces important pharmacological actions via interaction with a putative prostamide receptor
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide
(5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide i.e. prostamide F2alpha
-
?
1.11.1.20
thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate
Mus musculus
(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate i.e. prostaglandin H2. The product of the reaction prostaglandin F2alpha induces luteolysis in the estrous cycle and plays essential roles in parturition with its strong uterine contractile actions and has vasoconstriction and bronchoconstriction activities. PGF2alpha exerts these biological functions by binding to the FP receptor, a G-protein-coupled receptor that signals through Gq-mediated increases in intracellular calcium
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate
(5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate i.e. prostaglandin F2alpha
-
?
1.11.1.20
thioredoxin + prostaglandin H2
Mus musculus
-
thioredoxin disulfide + prostaglandin F2alpha
-
-
?
1.11.1.20
thioredoxin + prostamide H2
Mus musculus
-
thioredoxin disulfide + prostamide F2alpha
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.188
brain
enzyme is expressed preferentially in the white matter bundles of the entire central nervous system of adult mice with less marked expression inneuronal cell bodies. The enzyme co-localizes with myelin basic protein in myelin sheaths but not in axons
Mus musculus
-
1.1.1.188
myelin
enzyme co-localizes with myelin basic protein in myelin sheaths but not in axons
Mus musculus
-
1.1.1.188
oligodendrocyte
cultured oligodendrocytes at 7 days in vitro express the enzyme in cytoplasmic processes where the enzyme is co-localized with myelin basic protein
Mus musculus
-
1.11.1.20
brain
the enzyme is expressed preferentially in the white matter bundles of the entire central nervous system of adult mice with less marked expression in neuronal cell bodies. The enzyme is colocalized with myelin basic protein in myelin sheaths but not in axons. At the ultrastructural level, the enzyme is localized to myelin sheaths. Expression of the enzyme increases between postnatal day 9 and postnatal day 14 during the postnatal development, presumably in accordance with myelinogenesis
Mus musculus
-
1.11.1.20
central nervous system
prostamide/PGF synthase is expressed preferentially in the white matter bundles of the entire central nervous system of adult mice with less marked expression in neuronal cell bodies
Mus musculus
-
1.11.1.20
cerebellar cortex
-
Mus musculus
-
1.11.1.20
medulla oblongata
-
Mus musculus
-
1.11.1.20
myelin sheath
the enzyme is colocalized with myelin basic protein in myelin sheaths but not in axons
Mus musculus
-
1.11.1.20
oligodendrocyte
; cultured oligodendrocytes at 7 days in vitro express the enzyme in cytoplasmic processes where the enzyme is colocalized with myelin basic protein
Mus musculus
-
1.11.1.20
pons
-
Mus musculus
-
1.11.1.20
spinal cord
-
Mus musculus
-
1.11.1.20
white matter
there is a tendency for the white matter bundles in the spinal cord, medulla oblongata, pons, and cerebellar medulla to express prostamide/PGF synthase more strongly than those in other central nervous system regions
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.11.1.20
thioredoxin + (5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide
(5Z)-N-(2-hydroxyethyl)-7-[(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl]hept-5-enamide i.e. prostamide H2. The product of the reaction prostamide F2alpha is a COX-2-catalyzed metabolite of arachidonoyl ethanolamide that induces important pharmacological actions via interaction with a putative prostamide receptor
707934
Mus musculus
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide
(5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide i.e. prostamide F2alpha
-
-
?
1.11.1.20
thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate
(5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate i.e. prostaglandin H2. The product of the reaction prostaglandin F2alpha induces luteolysis in the estrous cycle and plays essential roles in parturition with its strong uterine contractile actions and has vasoconstriction and bronchoconstriction activities. PGF2alpha exerts these biological functions by binding to the FP receptor, a G-protein-coupled receptor that signals through Gq-mediated increases in intracellular calcium
707934
Mus musculus
thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate
(5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate i.e. prostaglandin F2alpha
-
-
?
1.11.1.20
thioredoxin + prostaglandin H2
-
707934
Mus musculus
thioredoxin disulfide + prostaglandin F2alpha
-
-
-
?
1.11.1.20
thioredoxin + prostamide H2
-
707934
Mus musculus
thioredoxin disulfide + prostamide F2alpha
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
1.1.1.188
Mus musculus
expression of the enzyme increases between P9 and P14 during the postnatal development, presumably in accordance with myelinogenesis
up
1.11.1.20
Mus musculus
the expression of prostamide/PGF synthase in myelin sheaths is age-dependent during the postnatal development, between postnatal days 9 and 14 the expression of the enzyme increases dramatically and preferentially in white matter bundles
up
Expression (protein specific)
EC Number
Organism
Commentary
Expression
1.1.1.188
Mus musculus
expression of the enzyme increases between P9 and P14 during the postnatal development, presumably in accordance with myelinogenesis
up
1.11.1.20
Mus musculus
the expression of prostamide/PGF synthase in myelin sheaths is age-dependent during the postnatal development, between postnatal days 9 and 14 the expression of the enzyme increases dramatically and preferentially in white matter bundles
up