Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Stathopoulou, P.; Galicia, J.; Benakanakere, M.; Garcia, C.; Potempa, J.; Kinane, D.
    Porphyromonas gingivalis induce apoptosis in human gingival epithelial cells through a gingipain-dependent mechanism (2009), BMC Microbiol., 9, 107.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.37 leupeptin human gingvial epithelial cells treated with Rgp-specific inhibitor leupeptin and challenged with Porphyromonas gingivalis cells do not undergo apoptosis Porphyromonas gingivalis
3.4.22.47 zFKck human gingvial epithelial cells treated with Kgp-specific inhibitor leupeptin and challenged with Porphyromonas gingivalis cells do not undergo apoptosis Porphyromonas gingivalis

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.37 Porphyromonas gingivalis
-
-
-
3.4.22.47 Porphyromonas gingivalis
-
-
-

Synonyms

EC Number Synonyms Comment Organism
3.4.22.37 Arg-gingipain A
-
 Porphyromonas gingivalis
3.4.22.37 Arg-gingipain B
-
 Porphyromonas gingivalis
3.4.22.37 RgpA
-
 Porphyromonas gingivalis
3.4.22.37 RgpB
-
 Porphyromonas gingivalis
3.4.22.47 KGP
-
 Porphyromonas gingivalis
3.4.22.47 Lys-gingipain
-
 Porphyromonas gingivalis

General Information

EC Number General Information Comment Organism
3.4.22.37 malfunction Porphyromonas gingivalis double mutant RgpA/RgpB cells do not induce apoptosis in human gingvial epithelial cells Porphyromonas gingivalis
3.4.22.37 physiological function live Porphyromonas gingivalis can invoke gingival epithelial cell apoptosis in a time and dose dependent manner with significant apoptosis occurring between 12 and 24 hours of challenge via a gingipain-dependent mechanism. Either arginine or lysine gingipains are necessary and sufficient factors in Porphyromonas gingivalis elicited apoptosis Porphyromonas gingivalis
3.4.22.47 malfunction Porphyromonas gingivalis triple mutant RgpA/RgpB/Kgp cells or the Lys-gingipain (Kgp) mutant K1A cells do not induce apoptosis in human gingvial epithelial cells Porphyromonas gingivalis
3.4.22.47 physiological function live Porphyromonas gingivalis can invoke gingival epithelial cell apoptosis in a time and dose dependent manner with significant apoptosis occurring between 12 and 24 hours of challenge via a gingipain-dependent mechanism. Either arginine or lysine gingipains are necessary and sufficient factors in Porphyromonas gingivalis elicited apoptosis Porphyromonas gingivalis