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Literature summary extracted from

  • Louie, B.; Rajamahanty, S.; Pyo, P.; Choudhury, M.; Konno, S.
    Mode of cytotoxic action of nephrotoxic agents: oxidative stress and glutathione-dependent enzyme (2010), BJU Int., 105, 264-268.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.5 buthionine sulfoximine 58% loss in Gly-I activity by 0.05 mM buthionine sulfoximine Homo sapiens
4.4.1.5 glycerol 64% loss in Gly-I activity by 2.5% (v/v) glycerol, Gly-I inactivation by glycerol is fully prevented or reversed by 0.5 mM N-acetylcysteine Homo sapiens
4.4.1.5 HgCl2 67% loss in Gly-I activity by 0.03 mM HgCl2, Gly-I inactivation by HgCl2 is fully prevented or reversed by 0.5 mM N-acetylcysteine Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.5 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.5 LLC-PK cell
-
 Homo sapiens
-
4.4.1.5 renal proximal tubule
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.5 methylglyoxal + glutathione
-
 Homo sapiens (R)-S-lactoylglutathione
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.5 gly-I
-
 Homo sapiens
4.4.1.5 glyoxalase I
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
4.4.1.5 glutathione
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
4.4.1.5 Homo sapiens Gly-I activity in N-acetylcysteine-exposed cells is 40% higher than that in control cells up

General Information

EC Number General Information Comment Organism
4.4.1.5 physiological function Gly-I plays a key role in cellular detoxification Homo sapiens