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Literature summary extracted from

  • Liu, M.; Yuan, M.; Luo, M.; Bu, X.; Luo, H.B.; Hu, X.
    Binding of curcumin with glyoxalase I: Molecular docking, molecular dynamics simulations, and kinetics analysis (2010), Biophys. Chem., 147, 28-34.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.5 bisdemethoxycurcumin
-
 Homo sapiens
4.4.1.5 curcumin efficient inhibitor Homo sapiens
4.4.1.5 indomethacin
-
 Homo sapiens
4.4.1.5 S-(N-hydroxy-N-p-iodophenylcarbamoyl) glutathione tight binding competitive inhibitor of human GLOI Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.5 Homo sapiens Q04760
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.5 methylglyoxal + glutathione
-
 Homo sapiens S-D-lactoylglutathione
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.5 GloI
-
 Homo sapiens
4.4.1.5 glyoxalase I
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
4.4.1.5 glutathione
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.4.1.5 0.0103
-
 bisdemethoxycurcumin
-
 Homo sapiens
4.4.1.5 0.0182
-
 curcumin
-
 Homo sapiens
4.4.1.5 0.0244
-
 indomethacin
-
 Homo sapiens