Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Yang, K.; Wang, Q.; Su, L.; Fang, H.; Wang, X.; Gong, J.; Wang, B.; Xu, W.
    Design and synthesis of novel chloramphenicol amine derivatives as potent aminopeptidase N (APN/CD13) inhibitors (2009), Bioorg. Med. Chem., 17, 3810-3817.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.2 (2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-N-pentylpropanamide
-
 Sus scrofa
3.4.11.2 (2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-N-phenethylpropanamide
-
 Sus scrofa
3.4.11.2 (2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-N-propylpropanamide
-
 Sus scrofa
3.4.11.2 (2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propanoic acid moderate APN inhibition Sus scrofa
3.4.11.2 (2R,3S)-2-amino-3-hydroxy-N-((S)-1-(hydroxyamino)-1-oxo-3-phenylpropan-2-yl)-3-(4-nitrophenyl)propanamide
-
 Sus scrofa
3.4.11.2 (2R,3S)-2-amino-3-hydroxy-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-3-(4-nitrophenyl)propanamide
-
 Sus scrofa
3.4.11.2 (2R,3S)-2-amino-3-hydroxy-N-(4-hydroxyphenethyl)-3-(4-nitrophenyl) propanamide
-
 Sus scrofa
3.4.11.2 (2R,3S)-2-amino-3-hydroxy-N-(4-methoxybenzyl)-3-(4-nitrophenyl)propanamide
-
 Sus scrofa
3.4.11.2 (2R,3S)-2-amino-3-hydroxy-N-isopropyl-3-(4-nitrophenyl)propanamide
-
 Sus scrofa
3.4.11.2 (2R,3S)-2-amino-N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-3-hydroxy-3-(4-nitrophenyl)propanamide
-
 Sus scrofa
3.4.11.2 (2R,3S)-2-amino-N-(2-chlorophenethyl)-3-hydroxy-3-(4-nitrophenyl)propanamide
-
 Sus scrofa
3.4.11.2 (2R,3S)-2-amino-N-(4-fluorobenzyl)-3-hydroxy-3-(4-nitrophenyl)propanamide
-
 Sus scrofa
3.4.11.2 (2R,3S)-2-amino-N-butyl-3-hydroxy-3-(4-nitrophenyl)propanamide
-
 Sus scrofa
3.4.11.2 (2R,3S)-2-amino-N-cyclohexyl-3-hydroxy-3-(4-nitrophenyl)propanamide
-
 Sus scrofa
3.4.11.2 (S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-3-(1H-indol-2-yl)propanoic acid
-
 Sus scrofa
3.4.11.2 (S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-3-methylbutanoic acid
-
 Sus scrofa
3.4.11.2 (S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-3-methylpentanoic acid
-
 Sus scrofa
3.4.11.2 (S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-3-phenylpropanoic acid
-
 Sus scrofa
3.4.11.2 (S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-4-methylpentanoic acid
-
 Sus scrofa
3.4.11.2 (S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-N-hydroxy-4-methylpentanamide
-
 Sus scrofa
3.4.11.2 (S)-2-((S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-3-phenylpropanamido)-3-phenylpropanoic acid
-
 Sus scrofa
3.4.11.2 (S)-2-((S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-4-methylpentanamido)-3-phenylpropanoic acid
-
 Sus scrofa
3.4.11.2 4-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)butanoic acid
-
 Sus scrofa
3.4.11.2 6-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)hexanoic acid
-
 Sus scrofa
3.4.11.2 bestatin
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.2 microsome
-
 Sus scrofa
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.2 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.2 kidney
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.2 L-Leu-4-nitroanilide + H2O
-
 Sus scrofa L-Leu + 4-nitroaniline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.2 aminopeptidase N
-
 Sus scrofa
3.4.11.2 APN
-
 Sus scrofa
3.4.11.2 CD13
-
 Sus scrofa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.11.2 0.003
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa bestatin
3.4.11.2 0.0071
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (S)-2-((S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-3-phenylpropanamido)-3-phenylpropanoic acid
3.4.11.2 0.0313
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (2R,3S)-2-amino-3-hydroxy-N-((S)-1-(hydroxyamino)-1-oxo-3-phenylpropan-2-yl)-3-(4-nitrophenyl)propanamide
3.4.11.2 0.0346
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (S)-2-((S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-4-methylpentanamido)-3-phenylpropanoic acid
3.4.11.2 0.0514
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (2R,3S)-2-amino-3-hydroxy-N-(4-hydroxyphenethyl)-3-(4-nitrophenyl) propanamide
3.4.11.2 0.054
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-N-hydroxy-4-methylpentanamide
3.4.11.2 0.0604
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-3-phenylpropanoic acid
3.4.11.2 0.0856
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-4-methylpentanoic acid
3.4.11.2 0.0903
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (2R,3S)-2-amino-N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-3-hydroxy-3-(4-nitrophenyl)propanamide
3.4.11.2 0.1028
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-3-methylpentanoic acid
3.4.11.2 0.1063
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-N-phenethylpropanamide
3.4.11.2 0.1163
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (2R,3S)-2-amino-3-hydroxy-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-3-(4-nitrophenyl)propanamide
3.4.11.2 0.1368
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (2R,3S)-2-amino-N-(2-chlorophenethyl)-3-hydroxy-3-(4-nitrophenyl)propanamide
3.4.11.2 0.1402
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propanoic acid
3.4.11.2 0.1447
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (2R,3S)-2-amino-3-hydroxy-N-(4-methoxybenzyl)-3-(4-nitrophenyl)propanamide
3.4.11.2 0.1599
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-3-methylbutanoic acid
3.4.11.2 0.1622
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (S)-2-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)-3-(1H-indol-2-yl)propanoic acid
3.4.11.2 0.1699
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-N-propylpropanamide
3.4.11.2 0.1832
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-N-propylpropanamide
3.4.11.2 0.2326
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (2R,3S)-2-amino-N-butyl-3-hydroxy-3-(4-nitrophenyl)propanamide
3.4.11.2 0.2507
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (2R,3S)-2-amino-3-hydroxy-N-isopropyl-3-(4-nitrophenyl)propanamide
3.4.11.2 0.2513
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (2R,3S)-2-amino-N-cyclohexyl-3-hydroxy-3-(4-nitrophenyl)propanamide
3.4.11.2 0.3025
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (2R,3S)-2-amino-N-(4-fluorobenzyl)-3-hydroxy-3-(4-nitrophenyl)propanamide
3.4.11.2 0.5217
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa (2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-N-pentylpropanamide
3.4.11.2 1.389
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa 6-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)hexanoic acid
3.4.11.2 2.891
-
 in 50 mM PBS buffer, pH 7.2, at 37°C Sus scrofa 4-((2R,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)-propanamido)butanoic acid