EC Number | Cloned (Comment) | Organism |
---|---|---|
4.4.1.5 | GST-GLOI fusion protein is expressed in Escherichia coli BL21 (DE3)pLysS cells | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.4.1.5 | (S)-4-bromobenzylglutathione cyclopentyl diester | competitive inhibitor of GLOI | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
4.4.1.5 | cytoplasm | - |
Homo sapiens | 5737 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.4.1.5 | methylglyoxal + glutathione | Homo sapiens | - |
(R)-S-lactoylglutathione | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.4.1.5 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
4.4.1.5 | Ni-NTA resin column chromatography | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
4.4.1.5 | HLE-B3 cell | - |
Homo sapiens | - |
4.4.1.5 | lens | GLOI is mainly localized in the anterior epithelium but the enzyme is diffusely present in outer cortical and nuclear regions of the human lens | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.4.1.5 | methylglyoxal + glutathione | - |
Homo sapiens | (R)-S-lactoylglutathione | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.4.1.5 | GloI | - |
Homo sapiens |
4.4.1.5 | glyoxalase I | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
4.4.1.5 | glutathione | - |
Homo sapiens |
EC Number | Organism | Comment | Expression |
---|---|---|---|
4.4.1.5 | Homo sapiens | in the human lens, GLOI activity and immunoreactivity both decrease with age | down |