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Literature summary extracted from

  • Oliveira, T.G.; Di Paolo, G.
    Phospholipase D in brain function and Alzheimer's disease (2010), Biochim. Biophys. Acta, 1801, 799-805.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.4 additional information PLD localization, overview Homo sapiens
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-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.4 phosphatidylcholine + H2O Homo sapiens
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choline + phosphatidic acid phosphatidic acid has unique bioactive properties and can modify both the physical and signalling properties of lipid bilayers. Perturbation of phosphatidic metabolism can alter membrane dynamics with consequences on cell viability, phosphatidic acid functions, overview ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Homo sapiens
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isozymes PLD1 and PLD2
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 brain
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Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.4 phosphatidylcholine + H2O
-
Homo sapiens choline + phosphatidic acid
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?
3.1.4.4 phosphatidylcholine + H2O
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Homo sapiens choline + phosphatidic acid phosphatidic acid has unique bioactive properties and can modify both the physical and signalling properties of lipid bilayers. Perturbation of phosphatidic metabolism can alter membrane dynamics with consequences on cell viability, phosphatidic acid functions, overview ?

Subunits

EC Number Subunits Comment Organism
3.1.4.4 More PLD structure, overview Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.4.4 PLD1
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Homo sapiens
3.1.4.4 PLD2
-
Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.4.4 malfunction phospholipase D, a phosphatidic acid-synthesizing enzyme, is linked to multiple aspects of normal brain function and to Alzheimer's disease, the most common neurodegenerative disorder, an imbalance in phospholipids is involved in development of Alzheimer's disease, overview Homo sapiens
3.1.4.4 physiological function PLD is especially involved in regulating biosynthesis and metabolism of phospholipids. Role of phospholipase D in amyloid-beta protein precursor, APP, trafficking, amyloid-beta protein generation, and in signaling mechanisms downstream of beta-amyloid as well as in the trafficking and processing of amyloid precursor protein. PLD1 positively regulates the delivery of PS1 to the cell surface in an APP-independent fashion. Role of the PLD pathway in brain regulation, PLD function, overview Homo sapiens