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Literature summary extracted from

  • Donaldson, J.G.
    Phospholipase D in endocytosis and endosomal recycling pathways (2009), Biochim. Biophys. Acta, 1791, 845-849.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.4 Arf proteins activate isozyme PLD1 and a truncated form of PLD2 Homo sapiens
3.1.4.4 phosphatidylinositol 3,4,5-trisphosphate binds to N-terminal phox consensus sequence of PLD1 and PLD2 Homo sapiens
3.1.4.4 phosphatidylinositol 4,5-bisphosphate binds to N-terminal pleckstrin homology of PLD1 and PLD2 Homo sapiens
3.1.4.4 Protein kinase C activates isozyme PLD1 Homo sapiens
3.1.4.4 Rho GTPases activate isozyme PLD1 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.4 endosome membrane PLD1 is associated with late endosomes and also at the plasma membrane. PLD2 is located at the plasma membrane and also associated with clathrin-independent endosomes in HeLa cells Homo sapiens 10008
-
3.1.4.4 plasma membrane PLD1 is associated with late endosomes and also at the plasma membrane. PLD2 is located at the plasma membrane and also associated with clathrin-independent endosomes in HeLa cells Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.4 phosphatidylcholine + H2O Homo sapiens
-
 choline + phosphatidic acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Homo sapiens
-
 isozynmes PLD1 and PLD2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.4 additional information during PLD stimulation of phosphatidylcholine hydrolysis, primary alcohols can replace water in the transphosphatidylation reaction forming phosphatidylbutanol instead of phosphatidic acid Homo sapiens ?
-
 ?
3.1.4.4 phosphatidylcholine + H2O
-
 Homo sapiens choline + phosphatidic acid
-
 ?
3.1.4.4 phosphatidylcholine + H2O the basal activity of PLD1 is lower than that of isozyme PLD2 Homo sapiens choline + phosphatidic acid
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.4.4 More the two PLDs have similar structure with amino terminal phox consensus sequence and pleckstrin homology domains, which bind to phosphatidylinositol 3,4,5-trisphosphate and PI4,5P2 respectively, followed by two catalytic domains in the second half of the protein Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.4.4 PLD
-
 Homo sapiens
3.1.4.4 PLD1
-
 Homo sapiens
3.1.4.4 PLD2
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.4.4 malfunction inhibition of RalA or PKC, activators of PLD, also inhibits endocytosis of EGFR Homo sapiens
3.1.4.4 physiological function phosphatidic acid, a lipid generated by PLD, favors membranes with negative curvature and thus can facilitate both membrane fission and fusion. Role for PLD in endocytosis and membrane recycling from endocytic pathways, overview. PLD is involved n internalization of signaling receptors in endocytosis Homo sapiens