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Literature summary extracted from

  • Taves, J.; Rastedt, D.; Canine, J.; Mork, D.; Wallert, M.A.; Provost, J.J.
    Sodium hydrogen exchanger and phospholipase D are required for alpha1-adrenergic receptor stimulation of metalloproteinase-9 and cellular invasion in CCL39 fibroblasts (2008), Arch. Biochem. Biophys., 477, 60-66.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.4 phenylephrine increases phosphatidylbutanol formation in CCL39 cells Cricetulus griseus
3.1.4.4 phosphatidylethanolamine activates PLD activity, leading to increased matrix metalloproteinase 9, MMP-9, activity Cricetulus griseus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.4 additional information inhibition of PLD significantly reduces the cell motility of CCL39 cells Cricetulus griseus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.4 phosphatidylcholine + H2O Cricetulus griseus
-
 choline + phosphatidic acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Cricetulus griseus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 DEDE cell a lung fibroblast cell line Cricetulus griseus
-
3.1.4.4 fibroblast
-
 Cricetulus griseus
-
3.1.4.4 fibrosarcoma cell
-
 Cricetulus griseus
-
3.1.4.4 lung
-
 Cricetulus griseus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.4 additional information PLD is also active in a transphosphatidylation assay with substrate 1-butanol resulting in production of phosphatidylbutanol Cricetulus griseus ?
-
 ?
3.1.4.4 phosphatidylcholine + H2O
-
 Cricetulus griseus choline + phosphatidic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.4 PLD
-
 Cricetulus griseus

General Information

EC Number General Information Comment Organism
3.1.4.4 physiological function PLD serves as a sigalling intermediate for activation of matrix metalloproteinase 9, MMP-9, that is critical in digesting the extracellular matrix and has a vital function in tumor metastasis and invasion, overview. PKC-dependent activation of MMP-9 in fibrosarcoma cells requires PLD activity Cricetulus griseus