BRENDA - Enzyme Database

Sodium hydrogen exchanger and phospholipase D are required for alpha1-adrenergic receptor stimulation of metalloproteinase-9 and cellular invasion in CCL39 fibroblasts

Taves, J.; Rastedt, D.; Canine, J.; Mork, D.; Wallert, M.A.; Provost, J.J.; Arch. Biochem. Biophys. 477, 60-66 (2008)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.4.4
phenylephrine
increases phosphatidylbutanol formation in CCL39 cells
Cricetulus griseus
3.1.4.4
phosphatidylethanolamine
activates PLD activity, leading to increased matrix metalloproteinase 9, MMP-9, activity
Cricetulus griseus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.4.4
additional information
inhibition of PLD significantly reduces the cell motility of CCL39 cells
Cricetulus griseus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.4.4
phosphatidylcholine + H2O
Cricetulus griseus
-
choline + phosphatidic acid
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.4.4
Cricetulus griseus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.4.4
CCL-39 cell
a lung fibroblast cell line
Cricetulus griseus
-
3.1.4.4
fibroblast
-
Cricetulus griseus
-
3.1.4.4
fibrosarcoma cell
-
Cricetulus griseus
-
3.1.4.4
lung
-
Cricetulus griseus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.4.4
additional information
PLD is also active in a transphosphatidylation assay with substrate 1-butanol resulting in production of phosphatidylbutanol
707273
Cricetulus griseus
?
-
-
-
-
3.1.4.4
phosphatidylcholine + H2O
-
707273
Cricetulus griseus
choline + phosphatidic acid
-
-
-
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.4.4
phenylephrine
increases phosphatidylbutanol formation in CCL39 cells
Cricetulus griseus
3.1.4.4
phosphatidylethanolamine
activates PLD activity, leading to increased matrix metalloproteinase 9, MMP-9, activity
Cricetulus griseus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.4.4
additional information
inhibition of PLD significantly reduces the cell motility of CCL39 cells
Cricetulus griseus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.4.4
phosphatidylcholine + H2O
Cricetulus griseus
-
choline + phosphatidic acid
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.4.4
CCL-39 cell
a lung fibroblast cell line
Cricetulus griseus
-
3.1.4.4
fibroblast
-
Cricetulus griseus
-
3.1.4.4
fibrosarcoma cell
-
Cricetulus griseus
-
3.1.4.4
lung
-
Cricetulus griseus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.4.4
additional information
PLD is also active in a transphosphatidylation assay with substrate 1-butanol resulting in production of phosphatidylbutanol
707273
Cricetulus griseus
?
-
-
-
-
3.1.4.4
phosphatidylcholine + H2O
-
707273
Cricetulus griseus
choline + phosphatidic acid
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
3.1.4.4
physiological function
PLD serves as a sigalling intermediate for activation of matrix metalloproteinase 9, MMP-9, that is critical in digesting the extracellular matrix and has a vital function in tumor metastasis and invasion, overview. PKC-dependent activation of MMP-9 in fibrosarcoma cells requires PLD activity
Cricetulus griseus
General Information (protein specific)
EC Number
General Information
Commentary
Organism
3.1.4.4
physiological function
PLD serves as a sigalling intermediate for activation of matrix metalloproteinase 9, MMP-9, that is critical in digesting the extracellular matrix and has a vital function in tumor metastasis and invasion, overview. PKC-dependent activation of MMP-9 in fibrosarcoma cells requires PLD activity
Cricetulus griseus