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Literature summary extracted from

  • van Schaftingen, E.; Collard, F.; Wiame, E.; Veiga-da-Cunha, M.
    Enzymatic repair of Amadori products (2012), Amino Acids, 42, 1143-1150.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.171 additional information diabetic subjects with the CC variant of SNP rs1056534 (G900C), which is associated with a higher FN3K activity, have lower HbA1c levels compared with other genotypes Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.171 ATP + [protein]-N6-D-fructosyl-L-lysine Homo sapiens
-
 ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine
-
 ?
2.7.1.171 ATP + [protein]-N6-D-fructosyl-L-lysine Mus musculus mice deficient in FN3K accumulate protein-bound fructosamines and free fructoselysine, indicating that the deglycation mechanism initiated by FN3K is operative in vivo ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.171 Homo sapiens
-
-
-
2.7.1.171 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.171
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.171 erythrocyte the human erythrocyte FN3K activity, which is stable with time in a single individual, is highly variable from person to person. This variability, which is linked to single nucleotide polymorphisms that are present in the FN3K gene, affects the glycation level of at least one specific site in haemoglobin Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.171 ATP + [protein]-N6-D-fructosyl-L-lysine
-
 Homo sapiens ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine
-
 ?
2.7.1.171 ATP + [protein]-N6-D-fructosyl-L-lysine mice deficient in FN3K accumulate protein-bound fructosamines and free fructoselysine, indicating that the deglycation mechanism initiated by FN3K is operative in vivo Mus musculus ADP + [protein]-N6-(O3-phosphono-D-fructosyl)-L-lysine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.171 FN3K
-
 Homo sapiens
2.7.1.171 fructose-3-kinase
-
 Mus musculus
2.7.1.171 fructose-3-kinase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.7.1.171 Homo sapiens no regulation of the expression of fructose-3-kinase is observed in human fibroblasts treated with conditions mimicking the hormonal and biochemical profile of the diabetic state additional information

General Information

EC Number General Information Comment Organism
2.7.1.171 malfunction mice deficient in FN3K accumulate protein-bound fructosamines and free fructoselysine, indicating that the deglycation mechanism initiated by FN3K is operative in vivo Mus musculus