Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Supinski, G.S.; Callahan, L.A.
    Calpain activation contributes to endotoxin-induced diaphragmatic dysfunction (2010), Am. J. Respir. Cell Mol. Biol., 42, 80-87.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.22.52 endotoxin treatment with 12 mg/kg endotoxin increases diaphragm calpain activity and active calpain I protein Mus musculus

Application

EC Number Application Comment Organism
3.4.22.52 medicine calpain inhibition attenuates endotoxin-induced diaphragm weakness, suggesting that such inhibitors may be a potential treatment to improve respiratory function in infected patients Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.52 calpain inhibitor peptide III
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.52 talin + H2O Mus musculus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.52 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.52 diaphragm
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.52 talin + H2O
-
 Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.52 calpain I
-
 Mus musculus

Expression

EC Number Organism Comment Expression
3.4.22.52 Mus musculus treatment with 12 mg/kg endotoxin increases active calpain I protein up