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Literature summary extracted from

  • Lee, S.K.; Kang, M.J.; Jin, C.; In, M.K.; Kim, D.H.; Yoo, H.H.
    Flavin-containing monooxygenase 1-catalysed N,N-dimethylamphetamine N-oxidation (2009), Xenobiotica, 39, 680-686.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.8 imipramine a FMO1-specific inhibitor, selectively inhibits N,N-dimethylamphetamine N-oxidation Homo sapiens
1.14.13.8 Methimazole inhibits N,N-dimethylamphetamine N-oxidation Homo sapiens
1.14.13.8 trimethylamine a FMO3-specific inhibitor, exhibits anegligible effect on the N,N-dimethylamphetamine N-oxide formation Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.13.8 additional information
-
 additional information Michaelis–Menten kinetics Homo sapiens
1.14.13.8 0.0445
-
 N,N-dimethylamphetamine pH 7.4, 37°C, FMO1 Homo sapiens
1.14.13.8 0.261
-
 N,N-dimethylamphetamine pH 7.4, 37°C, FMO3 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.8 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.8 N,N-dimethylamphetamine + NADPH + H+ + O2 Homo sapiens N-oxygenation mainly by isozyme FMO1, low activity with isozyme FMO3 N,N-dimethylamphetamine N-oxide + NADP+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.8 Homo sapiens Q01740 FMO1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.8 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.8 N,N-dimethylamphetamine + NADPH + H+ + O2 N-oxygenation mainly by isozyme FMO1, low activity with isozyme FMO3 Homo sapiens N,N-dimethylamphetamine N-oxide + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.13.8 FMO1
-
 Homo sapiens
1.14.13.8 FMO3
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.13.8 37
-
 assay at Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.14.13.8 60
-
 90 s, inactivation of FMO in liver microsomes Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.13.8 7.4
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.8 NADPH
-
 Homo sapiens