Literature summary extracted from

Yamamoto, A.; Nakatsu, S.; Kondo, A.; Asato, T.; Okabe, M.; Fukuzawa, M.; Miyagawa, S.
A newly cloned pig dolichyl-phosphate mannosyl-transferase for preventing the transmission of porcine endogenous retrovirus to human cells (2010), Transpl. Int., 23, 424-431.

Application

EC Number	Application	Comment	Organism
2.4.1.83	medicine	D-P-M enzyme activity represents a potentially useful approach to address the problem of porcine endogenous retrovirus infections in clinical xenotransplantations	Sus scrofa

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.4.1.83	cDNA fragments containing the start and stop codons amplified and subcloned into the EcoRV site of the pBluescript II SK(-) cloning vector	Sus scrofa

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.4.1.83	Sus scrofa	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.4.1.83	liver	-	Sus scrofa	-

Synonyms

EC Number	Synonyms	Comment	Organism
2.4.1.83	D-P-M	-	Sus scrofa
2.4.1.83	dolichyl-phosphate mannosyltransferase	-	Sus scrofa

Expression

EC Number	Organism	Comment	Expression
2.4.1.83	Sus scrofa	compared with the mock line, the temporary PEC(Z)/PB lines show a decreased mRNA expression for D-P-M and a clear destruction of porcine endogenous retrovirus infectivity to human cells in the Lac Z pseudotype assay. Compared with parental and mock cells, all PEC(Z)/PB cells transfected with siRNA show a decreased mRNA expression for the D-P-M by one-fifth	down

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Release 2023.1 (January 2023)