BRENDA - Enzyme Database show

Inhibition of thromboxane synthase activity improves glioblastoma response to alkylation chemotherapy

Schmidt, N.O.; Ziu, M.; Cargioli, T.; Westphal, M.; Giese, A.; Black, P.M.; Carroll, R.S.; Transl. Oncol. 3, 43-49 (2010)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
5.3.99.5
medicine
the targeted inhibition of TXSA activity improves the efficiency of conventional alkylation chemotherapy in vivo
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.5
furegrelate
specific inhibitor of TXSA
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.5
prostaglandin H2
Homo sapiens
-
thromboxane B2 + 12(S)-hydroxy-5,8,10-heptadecatrienoic acid
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.5
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.5
glioblastoma cell
-
Homo sapiens
-
5.3.99.5
U-87MG cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.5
prostaglandin H2
-
706861
Homo sapiens
thromboxane B2 + 12(S)-hydroxy-5,8,10-heptadecatrienoic acid
-
-
-
?
Application (protein specific)
EC Number
Application
Commentary
Organism
5.3.99.5
medicine
the targeted inhibition of TXSA activity improves the efficiency of conventional alkylation chemotherapy in vivo
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.5
furegrelate
specific inhibitor of TXSA
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.5
prostaglandin H2
Homo sapiens
-
thromboxane B2 + 12(S)-hydroxy-5,8,10-heptadecatrienoic acid
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.5
glioblastoma cell
-
Homo sapiens
-
5.3.99.5
U-87MG cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.5
prostaglandin H2
-
706861
Homo sapiens
thromboxane B2 + 12(S)-hydroxy-5,8,10-heptadecatrienoic acid
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
5.3.99.5
Homo sapiens
TXSA is upregulated in human glial tumors
up
Expression (protein specific)
EC Number
Organism
Commentary
Expression
5.3.99.5
Homo sapiens
TXSA is upregulated in human glial tumors
up