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Literature summary extracted from

  • Saidemberg, D.M.; Ferreira, M.A.; Takahashi, T.N.; Gomes, P.C.; Cesar-Tognoli, L.M.; da Silva-Filho, L.C.; Tormena, C.F.; da Silva, G.V.; Palma, M.S.
    Monoamine oxidase inhibitory activities of indolylalkaloid toxins from the venom of the colonial spider Parawixia bistriata: functional characterization of PwTX-I (2009), Toxicon, 54, 717-724.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 (+/-)-6-hydroxytrypargine an indolylalkaloid toxin enzyme inhibitor from the venom of the colonial spider Parawixia bistriata, synthesized by reaction of 5-hydroxytryptamine hydrochloride with N-(3-[1,3]dioxolan-2-yl-propyl)-guanidine sulfate, overview Homo sapiens
1.4.3.4 1-(4-guanidinobutoxy)-6-hydroxy-1,2,3,4-tetrahydro-beta-carboline an indolylalkaloid toxin enzyme inhibitor from the venom of the colonial spider Parawixia bistriata Homo sapiens
1.4.3.4 1-guanidino-6-hydroxy-3,5-dihydro-beta-carboline an indolylalkaloid toxin enzyme inhibitor from the venom of the colonial spider Parawixia bistriata Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.4 additional information
-
 additional information kinetics Homo sapiens
1.4.3.4 0.0165
-
 kynuramine pH 7.4, 37°C, MAO-B Homo sapiens
1.4.3.4 0.0652
-
 kynuramine pH 7.4, 37°C, MAO-A Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.4 commercial preparation MAO-A and MAO-B Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 kynuramine + H2O + O2
-
 Homo sapiens 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?
1.4.3.4 serotonin + H2O + O2
-
 Homo sapiens (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO-A
-
 Homo sapiens
1.4.3.4 MAO-B
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.4.3.4 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.3.4 7.4
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.4 flavin
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.3.4 additional information
-
 inhibition kinetics Homo sapiens additional information
1.4.3.4 0.008
-
 pH 7.4, 37°C, MAO-B Homo sapiens (-)-6-hydroxytrypargine
1.4.3.4 0.015
-
 pH 7.4, 37°C, MAO-B Homo sapiens (+)-6-hydroxytrypargine
1.4.3.4 0.034
-
 pH 7.4, 37°C, MAO-A Homo sapiens (-)-6-hydroxytrypargine
1.4.3.4 0.039
-
 pH 7.4, 37°C, MAO-A Homo sapiens (+)-6-hydroxytrypargine