Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Claesson, H.E.
    On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma (2009), Prostaglandins Other Lipid Mediat., 89, 120-125.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.33 mannitol osmotic activation of nasal tissue with mannitol activates 15-LO-1 leading to increased amounts of 15(S)-hydroxyeicosatetranoic acid in nasal lavage, and the levels of 15(S)-hydroxyeicosatetranoic acid are associated with nasal symptoms Homo sapiens

Application

EC Number Application Comment Organism
1.13.11.33 drug development 15-LO-1 is an attractive pharmacological target for treatment of inflammatory respiratory diseases like asthma, rhinitis and chronic obstructive pulmonary disease Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.33 glucocorticoid inhibits induction in monocytes Homo sapiens
1.13.11.33 interferon-gamma inhibits induction in monocytes Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.13.11.33 membrane enzyme is translocated to the membrane upon calcium challenge Homo sapiens 16020
-

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.33 Homo sapiens
-
-
-
1.13.11.33 Mus musculus
-
-
-
1.13.11.33 Oryctolagus cuniculus
-
-
-
1.13.11.33 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.33 alveolar macrophage medium expression Homo sapiens
-
1.13.11.33 colonic cancer cell low expression Homo sapiens
-
1.13.11.33 dendritic cell medium expression Homo sapiens
-
1.13.11.33 endothelial cell low expression Homo sapiens
-
1.13.11.33 eosinophil
-
 Sus scrofa
-
1.13.11.33 eosinophil high expression Homo sapiens
-
1.13.11.33 epithelial cell airway Mus musculus
-
1.13.11.33 epithelial cell airway, high expression in airway epithelial cells, medium expression in cornea epithelial cells Homo sapiens
-
1.13.11.33 fibroblast low expression Homo sapiens
-
1.13.11.33 mast cell medium expression Homo sapiens
-
1.13.11.33 additional information high expression in L-1236 cells (Hodgkin Reed–Sternberg cells), low expression in seminal fluid Homo sapiens
-
1.13.11.33 neutrophil low expression Homo sapiens
-
1.13.11.33 prostate cancer cell low expression Homo sapiens
-
1.13.11.33 reticulocyte
-
 Oryctolagus cuniculus
-
1.13.11.33 reticulocyte medium expression Homo sapiens
-
1.13.11.33 synovial cell low expression Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.33 arachidonate + O2
-
 Oryctolagus cuniculus (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
-
 ?
1.13.11.33 arachidonate + O2
-
 Mus musculus (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate main product is 12(S)-hydroxyeicosatetranoic acid ?
1.13.11.33 arachidonate + O2
-
 Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate product ratio is 9 to 1 ?
1.13.11.33 additional information 12/15-LO can catalyse the formation of EXC4 Sus scrofa ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.33 12/15-LO
-
 Mus musculus
1.13.11.33 12/15-LO
-
 Sus scrofa
1.13.11.33 15-lipoxygenase
-
 Oryctolagus cuniculus
1.13.11.33 15-lipoxygenase-1
-
 Homo sapiens
1.13.11.33 15-LO-1
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.13.11.33 Mus musculus allergen challenge up-regulates the expression of 12/15-LO in airway epithelial cells in mice. Interleukin-4 and interleukin-13 are inducers up
1.13.11.33 Homo sapiens increased expression and activity of 15-LO-1 in the respiratory tissue from asthma patients. Patients with chronic obstructive pulmonary disease also display an increased expression of 15-LO-1 in bronchial biopsies. Interleukin-4 and interleukin-13 are inducers up

General Information

EC Number General Information Comment Organism
1.13.11.33 physiological function pathophysiological role of the enzyme in airway inflammation and atherosclerosis. Role in cell differentiation and importance for maturation of erythrocytes and degradation of cell organells. Role in neoplasia such as prostate cancer and colon carcinoma cells Homo sapiens
1.13.11.33 physiological function pathophysiological role of the enzyme in respiratory inflammation. Mice deficient of 12/15-LO have an attenuated allergic airway inflammation compared to wild type controls Mus musculus