BRENDA - Enzyme Database show

The effects of microsomal prostaglandin E synthase-1 deletion in acute cardiac ischemia in mice

Wu, D.; Mennerich, D.; Arndt, K.; Sugiyama, K.; Ozaki, N.; Schwarz, K.; Wei, J.; Wu, H.; Bishopric, N.H.; Doods, H.; Prostaglandins Leukot. Essent. Fatty Acids 81, 31-33 (2009)

Data extracted from this reference:

Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.3
microsome
-
Mus musculus
-
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.3
Prostaglandin H2
Mus musculus
-
Prostaglandin E2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.3
Mus musculus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
Prostaglandin H2
-
706576
Mus musculus
Prostaglandin E2
-
-
-
?
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.3
microsome
-
Mus musculus
-
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.3
Prostaglandin H2
Mus musculus
-
Prostaglandin E2
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
Prostaglandin H2
-
706576
Mus musculus
Prostaglandin E2
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
5.3.99.3
malfunction
the deletion of mPGES-1 in mice results in increased prostacyclin I2 formation and marginal effects on the circulatory prostaglandin E2 level. Loss of mPGES-1 results in increased prostacyclin I2 formation, and in contrast to inhibition of prostacyclin I2, without worsening acute cardiac ischemic injury
Mus musculus
General Information (protein specific)
EC Number
General Information
Commentary
Organism
5.3.99.3
malfunction
the deletion of mPGES-1 in mice results in increased prostacyclin I2 formation and marginal effects on the circulatory prostaglandin E2 level. Loss of mPGES-1 results in increased prostacyclin I2 formation, and in contrast to inhibition of prostacyclin I2, without worsening acute cardiac ischemic injury
Mus musculus