BRENDA - Enzyme Database show

Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells

Sveinbjoernsson, B.; Schumacher, M.C.; Hamberg, M.; Samuelsson, B.; Jakobsson, P.J.; Kogner, P.; Radmark, O.; Proc. Natl. Acad. Sci. USA 106, 18757-18762 (2009)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
5.3.99.3
medicine
MPGES-1 is an alternative therapeutic target in cancer cells expressing this enzyme
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.3
microsome
-
Homo sapiens
-
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.3
Prostaglandin H2
Homo sapiens
-
Prostaglandin E2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.3
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.3
A-549 cell
-
Homo sapiens
-
5.3.99.3
DU-145 cell
-
Homo sapiens
-
5.3.99.3
additional information
MPGES-1 is not detected in LNCaP cells
Homo sapiens
-
5.3.99.3
PC-3 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
Prostaglandin H2
-
706521
Homo sapiens
Prostaglandin E2
-
-
-
?
Application (protein specific)
EC Number
Application
Commentary
Organism
5.3.99.3
medicine
MPGES-1 is an alternative therapeutic target in cancer cells expressing this enzyme
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.3
microsome
-
Homo sapiens
-
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.3
Prostaglandin H2
Homo sapiens
-
Prostaglandin E2
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.3
A-549 cell
-
Homo sapiens
-
5.3.99.3
DU-145 cell
-
Homo sapiens
-
5.3.99.3
additional information
MPGES-1 is not detected in LNCaP cells
Homo sapiens
-
5.3.99.3
PC-3 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
Prostaglandin H2
-
706521
Homo sapiens
Prostaglandin E2
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
5.3.99.3
Homo sapiens
interleukin-1beta does not change expression of MPGES-1 in the prostate cancer cell lines
additional information
Expression (protein specific)
EC Number
Organism
Commentary
Expression
5.3.99.3
Homo sapiens
interleukin-1beta does not change expression of MPGES-1 in the prostate cancer cell lines
additional information