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Literature summary extracted from

  • Sveinbjoernsson, B.; Schumacher, M.C.; Hamberg, M.; Samuelsson, B.; Jakobsson, P.J.; Kogner, P.; Radmark, O.
    Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells (2009), Proc. Natl. Acad. Sci. USA, 106, 18757-18762.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
5.3.99.3 medicine MPGES-1 is an alternative therapeutic target in cancer cells expressing this enzyme Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.99.3 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.3 Prostaglandin H2 Homo sapiens
-
 Prostaglandin E2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.3 A-549 cell
-
 Homo sapiens
-
5.3.99.3 DU-145 cell
-
 Homo sapiens
-
5.3.99.3 additional information MPGES-1 is not detected in LNCaP cells Homo sapiens
-
5.3.99.3 PC-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.3 Prostaglandin H2
-
 Homo sapiens Prostaglandin E2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.3 microsomal prostaglandin E synthase 1
-
 Homo sapiens
5.3.99.3 mPGES-1
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
5.3.99.3 Homo sapiens interleukin-1beta does not change expression of MPGES-1 in the prostate cancer cell lines additional information