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Literature summary extracted from

  • Mateuszuk, L.; Khomich, T.I.; Slominska, E.; Gajda, M.; Wojcik, L.; Lomnicka, M.; Gwozdz, P.; Chlopicki, S.
    Activation of nicotinamide N-methyltrasferase and increased formation of 1-methylnicotinamide (MNA) in atherosclerosis (2009), Pharmacol. Rep., 61, 76-85.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.1 cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.1 S-adenosyl-L-methionine + nicotinamide Mus musculus
-
 S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?
2.1.1.1 S-adenosyl-L-methionine + nicotinamide Mus musculus C57/BL6J
-
 S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.1 Mus musculus
-
 C57BL/6J mice
-
2.1.1.1 Mus musculus C57/BL6J
-
 C57BL/6J mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.1 adipose tissue
-
 Mus musculus
-
2.1.1.1 adrenal gland
-
 Mus musculus
-
2.1.1.1 brain
-
 Mus musculus
-
2.1.1.1 carcinoma cell
-
 Mus musculus
-
2.1.1.1 heart
-
 Mus musculus
-
2.1.1.1 kidney
-
 Mus musculus
-
2.1.1.1 liver high enzyme activity. Enzyme upregulation in vascular inflammation and atherosclerosis, overview Mus musculus
-
2.1.1.1 lung
-
 Mus musculus
-
2.1.1.1 placenta
-
 Mus musculus
-
2.1.1.1 skeletal muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.1 S-adenosyl-L-methionine + 4-methylnicotinamide assay for fluorometric determination of enzyme activity Mus musculus S-adenosyl-L-homocysteine + 1,4-dimethylnicotinamide
-
 ?
2.1.1.1 S-adenosyl-L-methionine + 4-methylnicotinamide assay for fluorometric determination of enzyme activity Mus musculus C57/BL6J S-adenosyl-L-homocysteine + 1,4-dimethylnicotinamide
-
 ?
2.1.1.1 S-adenosyl-L-methionine + nicotinamide
-
 Mus musculus S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?
2.1.1.1 S-adenosyl-L-methionine + nicotinamide
-
 Mus musculus C57/BL6J S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.1 NNMT
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.1 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.1 8.6
-
 assay at, substrate 4-methoxybenzaldehyde Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.1 S-adenosyl-L-methionine
-
 Mus musculus

Expression

EC Number Organism Comment Expression
2.1.1.1 Mus musculus progression of vascular inflammation and atherosclerosis is associated with the upregulation of hepatic NNMT activity and subsequent increase in endogenous 1-methylnicotinamide plasma levels up

General Information

EC Number General Information Comment Organism
2.1.1.1 physiological function progression of vascular inflammation and atherosclerosis is associated with the upregulation of hepatic NNMT activity and subsequent increase in endogenous 1-methylnicotinamide plasma levels Mus musculus