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Literature summary extracted from

  • Yi, W.; Fu, P.; Fan, Z.; Aso, H.; Tian, C.; Meng, Y.; Liu, J.; Yamori, Y.; Nara, Y.; Ying, C.
    Mitochondrial HMG-CoA synthase partially contributes to antioxidant protection in the kidney of stroke-prone spontaneously hypertensive rats (2010), Nutrition, 26, 1176-1180.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.3.10 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA Rattus norvegicus
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.3.10 Rattus norvegicus P22791 stroke-prone spontaneously hypertensive rats, SHRSPs, and their ancestral hypertensive but stroke-resistant spontaneously hypertensive rats, SHRs
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.3.10 kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.3.10 acetyl-CoA + H2O + acetoacetyl-CoA
-
 Rattus norvegicus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.3.10 3-hydroxy-3-methylglutaryl-coenzyme A synthase
-
 Rattus norvegicus
2.3.3.10 HMG-CoA synthase
-
 Rattus norvegicus
2.3.3.10 HMGCS2
-
 Rattus norvegicus
2.3.3.10 hydroxymethylglutaryl-CoA synthase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.3.10 CoA
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
2.3.3.10 Rattus norvegicus lower renal expression of HMGCS2 in SHRSPs than in SHRs or clofibrate-treated SHRSPs down