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Literature summary extracted from

  • Gilardi, F.; Viviani, B.; Galmozzi, A.; Boraso, M.; Bartesaghi, S.; Torri, A.; Caruso, D.; Crestani, M.; Marinovich, M.; de Fabiani, E.
    Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling (2009), Neuroscience, 164, 530-540.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.15.15 additional information astrocyte-restricted upregulation of Cyp27a1 due to to differential expression of transcriptional co-activators, increase of enzyme mRNA and protein levels in treated astrocytes is paralleled by transactivation of the proximal Cyp27a1 promoter in transfected astrocytes Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.15.15 CYP27 expression analysis in the brain Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.15.15 5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + H+ + O2 Rattus norvegicus
-
 (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + oxidized adrenodoxin + H2O
-
 ?
1.14.15.15 additional information Rattus norvegicus sterol 27-hydroxylase is regulated by liver X receptor signaling, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.15 Rattus norvegicus
-
 Sprague-Dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.15 astrocyte primary astrocytes express different sterol hydroxylases and are able to uptake exogenous 27-hydroxycholesterol Rattus norvegicus
-
1.14.15.15 brain Cyp27a1 is expressed in all the cell types but at highest levels in microglia Rattus norvegicus
-
1.14.15.15 central nervous system expression pattern of Cyp27a1 and other related genes in primary cultures of glia and neurons Rattus norvegicus
-
1.14.15.15 hippocampus
-
 Rattus norvegicus
-
1.14.15.15 microglia
-
 Rattus norvegicus
-
1.14.15.15 neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.15 5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + H+ + O2
-
 Rattus norvegicus (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + oxidized adrenodoxin + H2O
-
 ?
1.14.15.15 additional information sterol 27-hydroxylase is regulated by liver X receptor signaling, overview Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.15 CYP27
-
 Rattus norvegicus
1.14.15.15 sterol 27-hydroxylase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.15 NADPH
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
1.14.15.15 Rattus norvegicus astrocyte-restricted upregulation of Cyp27a1 due to to differential expression of transcriptional co-activators, increase of enzyme mRNA and protein levels in treated astrocytes is paralleled by transactivation of the proximal Cyp27a1 promoter in transfected astrocytes up

General Information

EC Number General Information Comment Organism
1.14.15.15 malfunction enzyme deficiency causes a disease characterized by progressive neurologic impairment. Impairment of CYP27 activity in astrocytes may alter critical features of the astrocytes, from the handling and delivery of cholesterol to neurons to the release of signaling molecules Rattus norvegicus
1.14.15.15 metabolism the enzyme is involved in cholesterol handling and metabolism Rattus norvegicus
1.14.15.15 physiological function pathophysiological role of CYP27A1 in the CNS Rattus norvegicus