BRENDA - Enzyme Database show

Protective role of hematopoietic prostaglandin D synthase in transient focal cerebral ischemia in mice

Liu, M.; Eguchi, N.; Yamasaki, Y.; Urade, Y.; Hattori, N.; Urabe, T.; Neuroscience 163, 296-307 (2009)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
5.3.99.2
medicine
the results demonstrate that the neuroprotective effects of hematopoietic prostaglandin D synthase in the model are mediated by suppression of activation and infiltration of inflammatory cells
Mus musculus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.2
4-benzhydryloxy-1-[3-(1H-tetrazol-5-yl)-propyl]piperidine
HQL-79
Mus musculus
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
5.3.99.2
26000
-
determined by SDS-PAGE and Western Blot analysis
Mus musculus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.2
Prostaglandin H2
Mus musculus
-
Prostaglandin D2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.2
Mus musculus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.2
brain
ischemic region, contralateral cortex
Mus musculus
-
5.3.99.2
microglia
-
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.2
Prostaglandin H2
-
705934
Mus musculus
Prostaglandin D2
-
-
-
?
Application (protein specific)
EC Number
Application
Commentary
Organism
5.3.99.2
medicine
the results demonstrate that the neuroprotective effects of hematopoietic prostaglandin D synthase in the model are mediated by suppression of activation and infiltration of inflammatory cells
Mus musculus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.2
4-benzhydryloxy-1-[3-(1H-tetrazol-5-yl)-propyl]piperidine
HQL-79
Mus musculus
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
5.3.99.2
26000
-
determined by SDS-PAGE and Western Blot analysis
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.2
Prostaglandin H2
Mus musculus
-
Prostaglandin D2
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.2
brain
ischemic region, contralateral cortex
Mus musculus
-
5.3.99.2
microglia
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.2
Prostaglandin H2
-
705934
Mus musculus
Prostaglandin D2
-
-
-
?