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Literature summary extracted from

  • Adjou, K.T.; Dilda, P.; Aumond, P.; Gueddari, S.; Deslys, J.P.; Dormont, D.; Seman, M.
    Increase of monoamine oxidase-B activity in the brain of scrapie-infected hamsters (2008), Neurochem. Int., 52, 1416-1421.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.4.3.4 additional information significant increase of cerebral MAO-B activity in scrapie-infected hamsters Mesocricetus auratus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 L-deprenyl irreversible cerebral MAO-B inhibitor Mesocricetus auratus
1.4.3.4 additional information the inhibitors show no neuroprotective effects in female scrapie-infected hamsters, overview Mesocricetus auratus
1.4.3.4 selegiline irreversible cerebral MAO-B inhibitor Mesocricetus auratus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.4 0.0004
-
 Phenylethylamine pH 7.4, 37°C, cerebral MAO-B Mesocricetus auratus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.4 phenylethylamine + H2O + O2 Mesocricetus auratus
-
 2-phenylethanal + NH3 + H2O2
-
 ?
1.4.3.4 serotonin + H2O + O2 Mesocricetus auratus
-
 (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Mesocricetus auratus
-
 female scrapie-infected hamsters
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.4 brain significant increase of cerebral MAO-B activity in scrapie-infected hamsters Mesocricetus auratus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 phenylethylamine + H2O + O2
-
 Mesocricetus auratus 2-phenylethanal + NH3 + H2O2
-
 ?
1.4.3.4 serotonin + H2O + O2
-
 Mesocricetus auratus (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO-A
-
 Mesocricetus auratus
1.4.3.4 MAO-B
-
 Mesocricetus auratus
1.4.3.4 monoamine oxidase-B
-
 Mesocricetus auratus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.4.3.4 37
-
 assay at Mesocricetus auratus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.3.4 7.4
-
 assay at Mesocricetus auratus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.3.4 0.0000014
-
 pH 7.4, 37°C, cerebral MAO-B Mesocricetus auratus L-deprenyl