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Literature summary extracted from

  • Buelow, D.R.; Raivio, T.L.
    Three (and more) component regulatory systems - auxiliary regulators of bacterial histidine kinases (2010), Mol. Microbiol., 75, 547-566.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.13.3 DivK acts as a stimulator of both PleC and DivJ kinase activity Caulobacter vibrioides
2.7.13.3 FixT stimulates FixL-mediated dephosphorylation of FixJ Sinorhizobium meliloti
2.7.13.3 LprF direct regulator of KdpD Escherichia coli
2.7.13.3 LprJ direct regulator of KdpD Escherichia coli
2.7.13.3 UhpC UhpC stimulates UhpB autophosphorylation in the presence of D-glucose 6-phosphate Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.13.3 FixT
-
 Caulobacter vibrioides
2.7.13.3 FixT
-
 Sinorhizobium meliloti
2.7.13.3 KipA
-
 Bacillus subtilis
2.7.13.3 Sda
-
 Bacillus subtilis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.13.3 membrane integral membrane protein Vibrio harveyi 16020
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.13.3 Bacillus subtilis
-
-
-
2.7.13.3 Bordetella pertussis
-
-
-
2.7.13.3 Caulobacter vibrioides
-
-
-
2.7.13.3 Escherichia coli
-
-
-
2.7.13.3 Sinorhizobium meliloti
-
-
-
2.7.13.3 Vibrio harveyi P54302
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.13.3 phosphoprotein
-
 Sinorhizobium meliloti
2.7.13.3 phosphoprotein
-
 Bacillus subtilis
2.7.13.3 phosphoprotein
-
 Escherichia coli
2.7.13.3 phosphoprotein
-
 Caulobacter vibrioides
2.7.13.3 phosphoprotein
-
 Bordetella pertussis
2.7.13.3 phosphoprotein
-
 Vibrio harveyi

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.13.3 ATP + BctC
-
 Bordetella pertussis ?
-
 ?
2.7.13.3 ATP + DivK DivJ is the main kinase of DivK Caulobacter vibrioides ?
-
 ?
2.7.13.3 ATP + FixJ
-
 Sinorhizobium meliloti ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.13.3 BctE
-
 Bordetella pertussis
2.7.13.3 CpxA
-
 Escherichia coli
2.7.13.3 DivJ
-
 Caulobacter vibrioides
2.7.13.3 EvgS
-
 Escherichia coli
2.7.13.3 FixL
-
 Sinorhizobium meliloti
2.7.13.3 KdpD
-
 Escherichia coli
2.7.13.3 KINA
-
 Bacillus subtilis
2.7.13.3 LuxQ
-
 Vibrio harveyi
2.7.13.3 PleC
-
 Caulobacter vibrioides
2.7.13.3 sensor histidine kinase
-
 Bacillus subtilis
2.7.13.3 TorS
-
 Escherichia coli
2.7.13.3 UhpB
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.13.3 ATP
-
 Bacillus subtilis
2.7.13.3 ATP
-
 Bordetella pertussis
2.7.13.3 ATP
-
 Vibrio harveyi

Expression

EC Number Organism Comment Expression
2.7.13.3 Vibrio harveyi regulated by the small molecule autoinducer AI-2 additional information

General Information

EC Number General Information Comment Organism
2.7.13.3 physiological function FixL utilizes a heme bound to an N-terminal PAS domain to detect the amount of oxygen present in the cytoplasm through direct binding Sinorhizobium meliloti
2.7.13.3 physiological function KdpD regulates the expression of potassium transporters in response to osmolarity Escherichia coli