BRENDA - Enzyme Database show

EtfA catalyses the formation of dipicolinic acid in Clostridium perfringens

Orsburn, B.C.; Melville, S.B.; Popham, D.L.; Mol. Microbiol. 75, 178-186 (2010)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
4.3.3.7
from pETSA1, overexpressed
Clostridium botulinum
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.3.3.7
Clostridium botulinum
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
4.3.3.7
-
Clostridium botulinum
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.3.3.7
L-aspartate 4-semialdehyde + pyruvate
-
705792
Clostridium botulinum
dihydrodipicolinate + 2 H2O
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
4.3.3.7
FAD
produces a 5fold increase in dipicolinic acid production
Clostridium botulinum
4.3.3.7
FMN
results in a 3fold increase in dipicolinic acid production
Clostridium botulinum
4.3.3.7
additional information
neither NAD+ nor NADP+ are involved in the production of dipicolinic acid
Clostridium botulinum
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
4.3.3.7
from pETSA1, overexpressed
Clostridium botulinum
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
4.3.3.7
FAD
produces a 5fold increase in dipicolinic acid production
Clostridium botulinum
4.3.3.7
FMN
results in a 3fold increase in dipicolinic acid production
Clostridium botulinum
4.3.3.7
additional information
neither NAD+ nor NADP+ are involved in the production of dipicolinic acid
Clostridium botulinum
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
4.3.3.7
-
Clostridium botulinum
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.3.3.7
L-aspartate 4-semialdehyde + pyruvate
-
705792
Clostridium botulinum
dihydrodipicolinate + 2 H2O
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
4.3.3.7
metabolism
sequential production of dihydrodipicolinate and dipicolinic acid appears to be catalysed by DHDPA synthase followed by an electron transfer flavoprotein, EtfA from Clostridium perfringens. Spontaneous dipicolinic acid formation in the presence of high concentrations of DapA
Clostridium botulinum
General Information (protein specific)
EC Number
General Information
Commentary
Organism
4.3.3.7
metabolism
sequential production of dihydrodipicolinate and dipicolinic acid appears to be catalysed by DHDPA synthase followed by an electron transfer flavoprotein, EtfA from Clostridium perfringens. Spontaneous dipicolinic acid formation in the presence of high concentrations of DapA
Clostridium botulinum