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Literature summary extracted from

  • Sproete, P.; Hynes, M.J.; Hortschansky, P.; Shelest, E.; Scharf, D.H.; Wolke, S.M.; Brakhage, A.A.
    Identification of the novel penicillin biosynthesis gene aatB of Aspergillus nidulans and its putative evolutionary relationship to this fungal secondary metabolism gene cluster (2008), Mol. Microbiol., 70, 445-461.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.164 additional information disruption of the aatA gene reduces penicillin production to 20%, the remaining activity is attributed to the product of gene aatB Aspergillus nidulans
2.3.1.164 additional information Overexpression of a mutated aatB-PTS1 gene in an aatA-disruption strain, leading to peroxisomal localization of AatB, increased the penicillin titre more than overexpression of the wild-type aatB. Aspergillus nidulans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.164 cytoplasm IAT encoded by the aatB gene, lacking a peroxisomal targeting signal PTS1 Aspergillus nidulans 5737
-
2.3.1.164 peroxisome IAT encoded by the aatA gene, containing a peroxisomal targeting signal PTS1 Aspergillus nidulans 5777
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.164 Aspergillus nidulans
-
-
-

Synonyms

EC Number Synonyms Comment Organism
2.3.1.164 aatA
-
 Aspergillus nidulans
2.3.1.164 aatA gene encoding isopenicillin N acyltransferase Aspergillus nidulans
2.3.1.164 aatB
-
 Aspergillus nidulans
2.3.1.164 aatB AN6775.3, gene encoding a penicillin V producing activity, which, in contrast to aatA, does not encode a peroxisomal targeting signal PTS1. aatB homologues also exist in non-penicillin-producing fungi and is suggested to be a paralogue of aatA. Aspergillus nidulans
2.3.1.164 acyl-coenzyme A: IPN acyltransferase
-
 Aspergillus nidulans
2.3.1.164 IAT
-
 Aspergillus nidulans
2.3.1.164 isopenicillin N acyltransferase
-
 Aspergillus nidulans

Expression

EC Number Organism Comment Expression
2.3.1.164 Aspergillus nidulans transcription factor AnBH1 acting as a repressor of aatA and aatB expression down
2.3.1.164 Aspergillus nidulans transcription factor AnCF acting as an activator of aatA and aatB expression up

General Information

EC Number General Information Comment Organism
2.3.1.164 metabolism catalyses final step of penicillin biosynthesis Aspergillus nidulans