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Literature summary extracted from

  • Liu, M.; Kirpekar, F.; van Wezel, G.P.; Douthwaite, S.
    The tylosin resistance gene tlrB of Streptomyces fradiae encodes a methyltransferase that targets G748 in 23S rRNA (2000), Mol. Microbiol., 37, 811-820.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.188 introduction of tlrB into Streptomyces lividans confers tylosin resistance Streptomyces fradiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.188 S-adenosyl-L-methionine + guanine748 in 23S rRNA Streptomyces fradiae in vivo TlrB modifies nucleotide G748 within helix 35 of 23S rRNA S-adenosyl-L-homocysteine + N1-methyluanine748 in 23S rRNA
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.188 Streptomyces fradiae Q9S1M6
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-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.188
-
 Streptomyces fradiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.188 S-adenosyl-L-methionine + guanine748 in 23S rRNA purified recombinant TlrB modifies G748 in 23S rRNA as well as in a 74 nucleotide RNA containing helix 35 and surrounding structures Streptomyces fradiae S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA
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 ?
2.1.1.188 S-adenosyl-L-methionine + guanine748 in 23S rRNA in vivo TlrB modifies nucleotide G748 within helix 35 of 23S rRNA Streptomyces fradiae S-adenosyl-L-homocysteine + N1-methyluanine748 in 23S rRNA
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.188 TlrB
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 Streptomyces fradiae