EC Number | Cloned (Comment) | Organism |
---|---|---|
4.1.3.1 | ICL loss-of-function mutant strain DELTAicl complemented with the functional ICL gene using the integrative vector pMV306 | Mycobacterium tuberculosis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.1.3.1 | Mycobacterium tuberculosis | P9WKK7 | - |
- |
4.1.3.1 | Mycobacterium tuberculosis H37Rv | P9WKK7 | - |
- |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.1.3.1 | ICL | - |
Mycobacterium tuberculosis |
4.1.3.1 | isocitrate lyase | - |
Mycobacterium tuberculosis |
EC Number | General Information | Comment | Organism |
---|---|---|---|
4.1.3.1 | malfunction | nutrient-starved bacilli lacking the glyoxylate shunt enzyme isocitrate lyase fail to reduce their intracellular ATP level and die, thus establishing a link between ATP control and intermediary metabolism. ICL loss-of-function mutant dies in the Loebel model. Viability is fully restored when the mutant strain is complemented with a wild-type copy of ICL | Mycobacterium tuberculosis |
4.1.3.1 | physiological function | ICL gene is required for non-growing survival in the Loebel model (nutrient deprivation in oxygen-rich medium) | Mycobacterium tuberculosis |