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Literature summary extracted from

  • Fang, W.; Yu, X.; Wang, B.; Zhou, H.; Ouyang, H.; Ming, J.; Jin, C.
    Characterization of the Aspergillus fumigatus phosphomannose isomerase Pmi1 and its impact on cell wall synthesis and morphogenesis (2009), Microbiology, 155, 3281-3293.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
5.3.1.8 additional information construction of a DELTApmi1 enzyme knockout mutant cell, that shows a significantly reduced growth rate at a high concentration of Man. Both inadequate and replete Man leads to an accumulation of intracellular Man-6-P and a reduction in the amount of alpha-glucan in the cell wall. Uncoupling of the link between energy production and glycosylation by deletion of the pmi1 gene leads to phenotypes such as defects in cell wall integrity, abnormal morphology and reduced conidiation, overview Aspergillus fumigatus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.3.1.8 Zn2+
-
 Aspergillus fumigatus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.1.8 D-Mannose 6-phosphate Aspergillus fumigatus
-
 D-Fructose 6-phosphate
-
 r
5.3.1.8 D-Mannose 6-phosphate Aspergillus fumigatus YJ-407
-
 D-Fructose 6-phosphate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
5.3.1.8 Aspergillus fumigatus Q66WM4 gene pmi1
-
5.3.1.8 Aspergillus fumigatus YJ-407 Q66WM4 gene pmi1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.1.8 D-Mannose 6-phosphate
-
 Aspergillus fumigatus D-Fructose 6-phosphate
-
 r
5.3.1.8 D-Mannose 6-phosphate
-
 Aspergillus fumigatus YJ-407 D-Fructose 6-phosphate
-
 r

Synonyms

EC Number Synonyms Comment Organism
5.3.1.8 Phosphomannose isomerase
-
 Aspergillus fumigatus
5.3.1.8 Pmi1
-
 Aspergillus fumigatus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
5.3.1.8 37
-
 assay at Aspergillus fumigatus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.3.1.8 7.6
-
 assay at Aspergillus fumigatus

General Information

EC Number General Information Comment Organism
5.3.1.8 malfunction uncoupling of the link between energy production and glycosylation by deletion of the pmi1 gene leads to phenotypes such as defects in cell wall integrity, abnormal morphology and reduced conidiation, overview Aspergillus fumigatus
5.3.1.8 metabolism the enzyme catalyzes the first committed step in the synthesis of mannose-containing sugar chains and provides a link between glucose metabolism and mannosylation Aspergillus fumigatus