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Literature summary extracted from

  • Amar, M.J.; Shamburek, R.D.; Vaisman, B.; Knapper, C.L.; Foger, B.; Hoyt, R.F.; Santamarina-Fojo, S.; Brewer, H.B.; Remaley, A.T.
    Adenoviral expression of human lecithin-cholesterol acyltransferase in nonhuman primates leads to an antiatherogenic lipoprotein phenotype by increasing high-density lipoprotein and lowering low-density lipoprotein (2009), Metab. Clin. Exp., 58, 568-575.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.43 apolipoprotein A-I kinetic analysis of radioiodinated ApoA-I associated with HDL and radioiodinated ApoB on LDL, mechanism for the effect of LCAT on lipid and lipoprotein changes, overview Homo sapiens

Application

EC Number Application Comment Organism
2.3.1.43 drug development LCAT is a potential drug target for reducing atherosclerosis Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.43 overexpression of LCAT in male nonhuman primate squirrel monkeys, Saimiri sciureus, using an adenoviral vector affects the lipoprotein metabolism, leading to an antiatherogenic lipoprotein profile by increasing HDL cholesterol and lowering ApoB, overview. Increased LCAT activity is also associated with a change in the size of HDL Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.43 extracellular the enzyme is secreted from liver to blood plasma Homo sapiens
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.43 phosphatidylcholine + cholesterol Homo sapiens LCAT is a plasma enzyme produced by the liver, that catalyzes the conversion of cholesterol to cholesteryl esters on lipoproteins by the transacylation of fatty acid from the sn-2 position of phosphatidylcholine to the 3-hydroxyl group on the A-ring of cholesterol cholesteryl ester + lysophosphatidylcholine
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Organism

EC Number Organism UniProt Comment Textmining
2.3.1.43 Homo sapiens
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.43 blood plasma
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Homo sapiens
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2.3.1.43 liver expression of LCAT Homo sapiens
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2.3.1.43 additional information most LCAT activity is found on high-density lipoprotein, HDL, but approximately 30% is also localized on apolipoprotein B-containing lipoproteins Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.43 phosphatidylcholine + cholesterol
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Homo sapiens cholesteryl ester + lysophosphatidylcholine
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2.3.1.43 phosphatidylcholine + cholesterol LCAT is a plasma enzyme produced by the liver, that catalyzes the conversion of cholesterol to cholesteryl esters on lipoproteins by the transacylation of fatty acid from the sn-2 position of phosphatidylcholine to the 3-hydroxyl group on the A-ring of cholesterol Homo sapiens cholesteryl ester + lysophosphatidylcholine
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?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.43 LCAT
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Homo sapiens
2.3.1.43 lecithin-cholesterol acyltransferase
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Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.43 metabolism LCAT is a key enzyme in high-density lipoprotein, HDL, metabolism Homo sapiens