EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
5.1.1.4 | pyrrole-2-carboxylic acid | inhibitor significantly affects parasite infection of Vero cells in vitro, inhibitor also hampers Trypanosoma cruzi intracellular differentiation, inhibitor reduces host cell invasion in Vero cells by Trypanososma cruzi in a dose-dependent manner, pre-treatment of the parasites with 1 mM of inhibitor does not lead to changes in their morphology and motility, but results in an up to 54% reduction in the percentage of parasitized cells and about 30% less parasites per cell when cultures are counted at day 4 after infection | Trypanosoma cruzi |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
5.1.1.4 | cytoplasm | TcPRAC localizes in the cytoplasm of intracellular amastigote forms of the parasite, near the flagellar pocket of the parasites | Trypanosoma cruzi | 5737 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.1.1.4 | L-proline | Trypanosoma cruzi | - |
D-proline | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.1.1.4 | Trypanosoma cruzi | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
5.1.1.4 | epimastigote | - |
Trypanosoma cruzi | - |
5.1.1.4 | metacyclic form | - |
Trypanosoma cruzi | - |
5.1.1.4 | trypomastigote | clone F11-F5 | Trypanosoma cruzi | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.1.1.4 | L-proline | - |
Trypanosoma cruzi | D-proline | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.1.1.4 | proline racemase | - |
Trypanosoma cruzi |
5.1.1.4 | TcPRAC | - |
Trypanosoma cruzi |
EC Number | Organism | Comment | Expression |
---|---|---|---|
5.1.1.4 | Trypanosoma cruzi | recombinant epimastigote parasites overexpressing TcPRAC genes coding for proline racemase present an augmented ability to differentiate into metacyclic infective forms and subsequently penetrate host-cells in vitro | additional information |
5.1.1.4 | Trypanosoma cruzi | in amastigote forms of the parasites, the intensity of anti-TcPRAC labeling varies according to the time post infection reaching the highest signal of TcPRAC expression after 48 h, while the number of intracellular parasites increases by amastigote multiplication | up |
EC Number | General Information | Comment | Organism |
---|---|---|---|
5.1.1.4 | physiological function | proline racemase is an effective mitogen for B cells, thus contributing to the parasites immune evasion and persistence in the human host | Trypanosoma cruzi |