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Literature summary extracted from
- Cytochrome P-450(17alpha) in beta-cells of rat pancreas and its local steroidogenesis (2008), J. Steroid Biochem. Mol. Biol., 111, 80-86.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.19 | additional information | inhibition with anti-P-450 reductase or limitation of NADPH preferentially reduce the lyase activity | Rattus norvegicus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.14.19 | microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.19 | additional information | Rattus norvegicus | CYP17 existence coincide with that of insulin and demarcated those of glucagon and somatostatin | ? | - |
? |  |
| 1.14.14.19 | progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Rattus norvegicus | - |
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.19 | Rattus norvegicus | - |
male sprague-dawley rats | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.14.14.19 | native enzyme partially from pancreatic cell microsomes | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.19 | Langerhans cell | - |
Rattus norvegicus | - |
| 1.14.14.19 | additional information | immunohistochemic enzyme localization analysis, overview | Rattus norvegicus | - |
| 1.14.14.19 | pancreas | islets of Langerhans | Rattus norvegicus | - |
| 1.14.14.19 | pancreatic beta cell | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.19 | additional information | CYP17 existence coincide with that of insulin and demarcated those of glucagon and somatostatin | Rattus norvegicus | ? | - |
? | |
| 1.14.14.19 | progesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.14.19 | cytochrome P-45017alpha | - |
Rattus norvegicus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.19 | 25 | - |
assay at | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.19 | 7.5 | - |
assay at | Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.19 | NADPH | dependent on | Rattus norvegicus | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.14.19 | metabolism | Cyp17 is important in the metabolism of androgens, overview | Rattus norvegicus |
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Release 2023.1 (January 2023)
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