BRENDA - Enzyme Database show

Prostaglandin D2 produced by hematopoietic prostaglandin D synthase contributes to LPS-induced fever

Gao, W.; Schmidtko, A.; Wobst, I.; Lu, R.; Angioni, C.; Geisslinger, G.; J. Physiol. Pharmacol. 60(2), 145-150 (2009)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
5.3.99.2
medicine
prostaglandin D2 produced by hematopoietic prostaglandin D synthase contributes to lipopolysaccharide-induced fever
Rattus norvegicus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.2
EDJ300520
-
Rattus norvegicus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.2
Prostaglandin H2
Rattus norvegicus
-
Prostaglandin D2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.2
Rattus norvegicus
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.2
Prostaglandin H2
-
705351
Rattus norvegicus
Prostaglandin D2
-
-
-
?
Application (protein specific)
EC Number
Application
Commentary
Organism
5.3.99.2
medicine
prostaglandin D2 produced by hematopoietic prostaglandin D synthase contributes to lipopolysaccharide-induced fever
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.2
EDJ300520
-
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.2
Prostaglandin H2
Rattus norvegicus
-
Prostaglandin D2
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.2
Prostaglandin H2
-
705351
Rattus norvegicus
Prostaglandin D2
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
5.3.99.2
Rattus norvegicus
oral pretreatment with the inhibitor EDJ300520 prevents the lipopolysaccharide-induced PGD2 increase in plasma and lungs
down
5.3.99.2
Rattus norvegicus
the synthesis of PGD2 is increased in plasma and lungs in response to systemic lipopolysaccharide injection
up
Expression (protein specific)
EC Number
Organism
Commentary
Expression
5.3.99.2
Rattus norvegicus
oral pretreatment with the inhibitor EDJ300520 prevents the lipopolysaccharide-induced PGD2 increase in plasma and lungs
down
5.3.99.2
Rattus norvegicus
the synthesis of PGD2 is increased in plasma and lungs in response to systemic lipopolysaccharide injection
up