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Literature summary extracted from

  • Hokari, R.; Nagata, N.; Kurihara, C.; Watanabe, C.; Komoto, S.; Okada, Y.; Kawaguchi, A.; Nagao, S.; Hibi, T.; Nagata, K.; Urade, Y.; Miura, S.
    Increased expression and cellular localization of lipocalin-type prostaglandin D synthase in Helicobacter pylori-induced gastritis (2009), J. Pathol., 219, 417-426.
    View publication on PubMed

Application

EC Number Application Comment Organism
5.3.99.2 medicine based on the observations it is speculated that PGD2 acts as one of the immuno-modulating molecules in gastric mucosa infected with Helicobacter pylori, PGD2 might be involved in the pathophysiology of other gastric diseases, such as gastric ulcers or erosion Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.3.99.2 the coding region of human L-PGDS is sub-cloned into pCR-Script Amp SK+ vector Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.2 Prostaglandin H2 Homo sapiens
-
 Prostaglandin D2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.2 fibroblast
-
 Homo sapiens
-
5.3.99.2 gastric mucosa
-
 Homo sapiens
-
5.3.99.2 glandular epithelium L-PGDS is constitutively expressed in the epithelium of the glandular base Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.2 Prostaglandin H2
-
 Homo sapiens Prostaglandin D2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.2 H-PGDS
-
 Homo sapiens
5.3.99.2 haematopoietic prostaglandin D synthase
-
 Homo sapiens
5.3.99.2 L-PGDS
-
 Homo sapiens
5.3.99.2 lipocalin-type prostaglandin d synthase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
5.3.99.2 Homo sapiens level of L-PGDS mRNA expression decreases as gastritis becomes more severe down
5.3.99.2 Homo sapiens L-PGDS, but not H-PGDS, is induced on fibroblasts close to infiltrating cells in the Helicobacter pylori-infected gastric mucosa up