BRENDA - Enzyme Database show

Increased expression and cellular localization of lipocalin-type prostaglandin D synthase in Helicobacter pylori-induced gastritis

Hokari, R.; Nagata, N.; Kurihara, C.; Watanabe, C.; Komoto, S.; Okada, Y.; Kawaguchi, A.; Nagao, S.; Hibi, T.; Nagata, K.; Urade, Y.; Miura, S.; J. Pathol. 219, 417-426 (2009)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
5.3.99.2
medicine
based on the observations it is speculated that PGD2 acts as one of the immuno-modulating molecules in gastric mucosa infected with Helicobacter pylori, PGD2 might be involved in the pathophysiology of other gastric diseases, such as gastric ulcers or erosion
Homo sapiens
Cloned(Commentary)
EC Number
Commentary
Organism
5.3.99.2
the coding region of human L-PGDS is sub-cloned into pCR-Script Amp SK+ vector
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.2
Prostaglandin H2
Homo sapiens
-
Prostaglandin D2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.2
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.2
fibroblast
-
Homo sapiens
-
5.3.99.2
gastric mucosa
-
Homo sapiens
-
5.3.99.2
glandular epithelium
L-PGDS is constitutively expressed in the epithelium of the glandular base
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.2
Prostaglandin H2
-
705307
Homo sapiens
Prostaglandin D2
-
-
-
?
Application (protein specific)
EC Number
Application
Commentary
Organism
5.3.99.2
medicine
based on the observations it is speculated that PGD2 acts as one of the immuno-modulating molecules in gastric mucosa infected with Helicobacter pylori, PGD2 might be involved in the pathophysiology of other gastric diseases, such as gastric ulcers or erosion
Homo sapiens
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
5.3.99.2
the coding region of human L-PGDS is sub-cloned into pCR-Script Amp SK+ vector
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.2
Prostaglandin H2
Homo sapiens
-
Prostaglandin D2
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.2
fibroblast
-
Homo sapiens
-
5.3.99.2
gastric mucosa
-
Homo sapiens
-
5.3.99.2
glandular epithelium
L-PGDS is constitutively expressed in the epithelium of the glandular base
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.2
Prostaglandin H2
-
705307
Homo sapiens
Prostaglandin D2
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
5.3.99.2
Homo sapiens
level of L-PGDS mRNA expression decreases as gastritis becomes more severe
down
5.3.99.2
Homo sapiens
L-PGDS, but not H-PGDS, is induced on fibroblasts close to infiltrating cells in the Helicobacter pylori-infected gastric mucosa
up
Expression (protein specific)
EC Number
Organism
Commentary
Expression
5.3.99.2
Homo sapiens
level of L-PGDS mRNA expression decreases as gastritis becomes more severe
down
5.3.99.2
Homo sapiens
L-PGDS, but not H-PGDS, is induced on fibroblasts close to infiltrating cells in the Helicobacter pylori-infected gastric mucosa
up