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Literature summary extracted from

  • Wijeratne, S.S.; Camporeale, G.; Zempleni, J.
    K12-biotinylated histone H4 is enriched in telomeric repeats from human lung IMR-90 fibroblasts (2010), J. Nutr. Biochem., 21, 310-316.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.4.10 ATP + biotin + apo-[propionyl-CoA carboxylase] Homo sapiens
-
 AMP + diphosphate + propionyl-CoA carboxylase
-
 ?
6.3.4.10 ATP + biotin + histone H4 Homo sapiens biotinylation at Lys12 especially in telomeric repeats, overview AMP + diphosphate + biotin-histone H4
-
 ?
6.3.4.15 ATP + biotin + apo-[acetyl-CoA carboxylase 1] Homo sapiens cytoplasmic acetyl-CoA carboxylase isozyme AMP + diphosphate + acetyl-CoA carboxylase 1
-
 ?
6.3.4.15 ATP + biotin + apo-[acetyl-CoA carboxylase 2] Homo sapiens mitochondrial acetyl-CoA carboxylase isozyme AMP + diphosphate + acetyl-CoA carboxylase 2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.10 Homo sapiens
-
-
-
6.3.4.15 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.4.10 fibroblast
-
 Homo sapiens
-
6.3.4.10 IMR-90 cell lung fibroblasts, quantitative determination of HCS in wild-type IMR-90 fibroblasts and in those recombinantly overexpressing human telomerase, evaluation as a cell model for investigation of HCS in epigenetic regulation, histone biotinylation in aging cells, overview Homo sapiens
-
6.3.4.15 fibroblast
-
 Homo sapiens
-
6.3.4.15 IMR-90 cell lung fibroblasts, quantitative determination of HCS in wild-type IMR-90 fibroblasts and in those recombinantly overexpressing human telomerase, evaluation as a cell model for investigation of HCS in epigenetic regulation, histone biotinylation in aging cells, overview Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.10 ATP + biotin + apo-[propionyl-CoA carboxylase]
-
 Homo sapiens AMP + diphosphate + propionyl-CoA carboxylase
-
 ?
6.3.4.10 ATP + biotin + histone H4 biotinylation at Lys12 especially in telomeric repeats, overview Homo sapiens AMP + diphosphate + biotin-histone H4
-
 ?
6.3.4.15 ATP + biotin + apo-[acetyl-CoA carboxylase 1] cytoplasmic acetyl-CoA carboxylase isozyme Homo sapiens AMP + diphosphate + acetyl-CoA carboxylase 1
-
 ?
6.3.4.15 ATP + biotin + apo-[acetyl-CoA carboxylase 2] mitochondrial acetyl-CoA carboxylase isozyme Homo sapiens AMP + diphosphate + acetyl-CoA carboxylase 2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.4.10 HCS
-
 Homo sapiens
6.3.4.10 Holocarboxylase synthetase
-
 Homo sapiens
6.3.4.15 HCS
-
 Homo sapiens
6.3.4.15 Holocarboxylase synthetase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
6.3.4.10 physiological function biotinylation of lysine residues in histones by holocarboxylase synthetase is an epigenetic diet-dependent mechanism to regulate chromatin structure and gene expression Homo sapiens