BRENDA - Enzyme Database show

Endothelial microsomal prostaglandin E synthase-1 exacerbates neuronal loss induced by kainate

Takemiya, T.; Matsumura, K.; Sugiura, H.; Maehara, M.; Yasuda, S.; Uematsu, S.; Akira, S.; Yamagata, K.; J. Neurosci. Res. 88, 381-390 (2010)

Data extracted from this reference:

Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.3
Mus musculus
-
-
-
5.3.99.3
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.3
brain
-
Rattus norvegicus
-
5.3.99.3
brain
-
Mus musculus
-
5.3.99.3
hippocampus
-
Mus musculus
-
5.3.99.3
hippocampus
-
Rattus norvegicus
-
5.3.99.3
venous endothelial cell
-
Mus musculus
-
5.3.99.3
venous endothelial cell
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
Prostaglandin H2
-
705284
Mus musculus
Prostaglandin E2
-
-
-
?
5.3.99.3
Prostaglandin H2
-
705284
Rattus norvegicus
Prostaglandin E2
-
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.3
brain
-
Rattus norvegicus
-
5.3.99.3
brain
-
Mus musculus
-
5.3.99.3
hippocampus
-
Mus musculus
-
5.3.99.3
hippocampus
-
Rattus norvegicus
-
5.3.99.3
venous endothelial cell
-
Mus musculus
-
5.3.99.3
venous endothelial cell
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
Prostaglandin H2
-
705284
Mus musculus
Prostaglandin E2
-
-
-
?
5.3.99.3
Prostaglandin H2
-
705284
Rattus norvegicus
Prostaglandin E2
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
5.3.99.3
Mus musculus
microinjection of kainic acid induces mPGES-1 in venous endothelial cells but not in neurons or astrocytes
up
5.3.99.3
Rattus norvegicus
microinjection of kainic acid induces mPGES-1 in venous endothelial cells but not in neurons or astrocytes
up
General Information
EC Number
General Information
Commentary
Organism
5.3.99.3
malfunction
mPGES-1-deficient mice exhibit significantly less neuronal loss induced by kainic acid
Mus musculus
General Information (protein specific)
EC Number
General Information
Commentary
Organism
5.3.99.3
malfunction
mPGES-1-deficient mice exhibit significantly less neuronal loss induced by kainic acid
Mus musculus
Expression (protein specific)
EC Number
Organism
Commentary
Expression
5.3.99.3
Mus musculus
microinjection of kainic acid induces mPGES-1 in venous endothelial cells but not in neurons or astrocytes
up
5.3.99.3
Rattus norvegicus
microinjection of kainic acid induces mPGES-1 in venous endothelial cells but not in neurons or astrocytes
up