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Literature summary extracted from

  • Takemiya, T.; Matsumura, K.; Sugiura, H.; Maehara, M.; Yasuda, S.; Uematsu, S.; Akira, S.; Yamagata, K.
    Endothelial microsomal prostaglandin E synthase-1 exacerbates neuronal loss induced by kainate (2010), J. Neurosci. Res., 88, 381-390.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.3 Mus musculus
-
-
-
5.3.99.3 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.3 brain
-
 Mus musculus
-
5.3.99.3 brain
-
 Rattus norvegicus
-
5.3.99.3 hippocampus
-
 Mus musculus
-
5.3.99.3 hippocampus
-
 Rattus norvegicus
-
5.3.99.3 venous endothelial cell
-
 Mus musculus
-
5.3.99.3 venous endothelial cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.3 Prostaglandin H2
-
 Mus musculus Prostaglandin E2
-
 ?
5.3.99.3 Prostaglandin H2
-
 Rattus norvegicus Prostaglandin E2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.3 microsomal prostaglandin E synthase-1
-
 Mus musculus
5.3.99.3 microsomal prostaglandin E synthase-1
-
 Rattus norvegicus
5.3.99.3 mPGES-1
-
 Mus musculus
5.3.99.3 mPGES-1
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
5.3.99.3 Mus musculus microinjection of kainic acid induces mPGES-1 in venous endothelial cells but not in neurons or astrocytes up
5.3.99.3 Rattus norvegicus microinjection of kainic acid induces mPGES-1 in venous endothelial cells but not in neurons or astrocytes up

General Information

EC Number General Information Comment Organism
5.3.99.3 malfunction mPGES-1-deficient mice exhibit significantly less neuronal loss induced by kainic acid Mus musculus