BRENDA - Enzyme Database show

Inhibition of invasion-associated thromboxane synthase sensitizes experimental gliomas to gamma-radiation

Schauff, A.; Kim, E.; Leppert, J.; Nadrowitz, R.; Wuestenberg, R.; Brockmann, M.; Giese, A.; J. Neurooncol. 91, 241-249 (2009)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.5
furegrelate
specific inhibitor of thromboxane synthase, i.e. sodium 5-(3-pyridinylmethyl) benzofuran-2-carboxylate
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.5
prostaglandin H2
Homo sapiens
-
thromboxane B2 + 12(S)-hydroxy-5,8,10-heptadecatrienoic acid
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.5
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.5
glioma cell
-
Homo sapiens
-
5.3.99.5
U-87MG cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.5
prostaglandin H2
-
705275
Homo sapiens
thromboxane B2 + 12(S)-hydroxy-5,8,10-heptadecatrienoic acid
-
-
-
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.5
furegrelate
specific inhibitor of thromboxane synthase, i.e. sodium 5-(3-pyridinylmethyl) benzofuran-2-carboxylate
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.5
prostaglandin H2
Homo sapiens
-
thromboxane B2 + 12(S)-hydroxy-5,8,10-heptadecatrienoic acid
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.5
glioma cell
-
Homo sapiens
-
5.3.99.5
U-87MG cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.5
prostaglandin H2
-
705275
Homo sapiens
thromboxane B2 + 12(S)-hydroxy-5,8,10-heptadecatrienoic acid
-
-
-
?